Inhibition of Staphylococcus epidermidis colonization with fusidic acid-impregnated catheters

Basit Öğe Kaydı
dc.contributor.authorAğalar, Canan
dc.contributor.authorKılıç, Dilek
dc.contributor.authorÇeken, Sabahat
dc.contributor.authorÖzdoğan, Mehmet
dc.contributor.authorYasar, Erdem
dc.contributor.authorÖztürk, Eylem
dc.contributor.authorDenkbaş, Emir Baki
dc.date.accessioned2020-06-25T17:43:57Z
dc.date.available2020-06-25T17:43:57Z
dc.date.issued2007
dc.descriptionGUVEN, EYLEM/0000-0001-9039-1698
dc.description.abstractThe aim of this study was the preparation and characterization of fusidic acid-impregnated peripheral catheters. In the first part of the study, in vitro drug release studies were performed, and the effect of fusidic acid impregnation on adherence of slime positive Staphylococcus epidermidis to catheters was evaluated as in vitro studies. Fusidic acid-impregnated and naive catheters were incubated with 10(8) colony forming unit/mL (cfu/mL) slime positive S. epidermidis during the in vitro experiment. After incubation for 2, 4, 6, 8, 12, 24, 48, and 72 h, the number of colonies were determined in an aliquot and adhered to the catheter. During the in vivo experiment, contaminated naive and fusidic acid-impregnated catheters (n = 10 rats in both groups) were implanted subcutaneously in the back of the rats. Rats were killed at the end of the seventh day and catheters were removed. Microbiologic assessments from the explanted catheter segments were performed. Fusidic acid impregnation decreased the number of adherent bacteria to the catheters and the number of free bacteria within the liquid medium significantly. There were 3 positive catheter cultures out of 10 in rats implanted with fusidic acid-impregnated catheters, whereas all explanted catheters from naive group yielded bacterial growth. The mean cfu counts were significantly less in the fusidic acid-impregnated catheter group. In vitro release studies and antibacterial activity studies correlated well. Additionally, morphological evaluations by scanning electron microscopy showed that fewer bacteria were evident on the fusidic acid-impregnated catheters compared with naive catheters. As a conclusion, catheter impregnation with fusidic acid is effective in preventing colonization in these in vitro and in vivo sets of experiments, with slime-producing S. epidermidis.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1177/0883911507076457
dc.identifier.endpage173en_US
dc.identifier.issn0883-9115
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-33947391346
dc.identifier.scopusqualityQ3
dc.identifier.startpage160en_US
dc.identifier.urihttps://doi.org10.1177/0883911507076457
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3954
dc.identifier.volume22en_US
dc.identifier.wosWOS:000244974500003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal Of Bioactive And Compatible Polymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfusidic aciden_US
dc.subjectimpregnationen_US
dc.subjectcatheteren_US
dc.subjectStaphylococcus epidermidisen_US
dc.subjectcatheter-related infectionen_US
dc.subjectdrug releaseen_US
dc.titleInhibition of Staphylococcus epidermidis colonization with fusidic acid-impregnated cathetersen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Inhibition of Staphylococcus epidermidis colonization with fusidic acid-impregnated catheters.pdf
Boyut:
950.8 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu