Corneal Sensitivity and Tear Function in Neurodegenerative Diseases

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dc.contributor.authorOrnek, Nurgul
dc.contributor.authorDag, Ersel
dc.contributor.authorOrnek, Kemal
dc.date.accessioned2020-06-25T18:13:26Z
dc.date.available2020-06-25T18:13:26Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionOrnek, Nurgul/0000-0003-3068-1831
dc.description.abstractPurpose: To measure corneal sensitivity and tear function in neurodegenerative diseases (NDs) and to compare them with age and sex-matched controls. Methods: Twenty patients with Alzheimer's disease (AD), 20 patients with multiple sclerosis (MS), 30 patients with Parkinson's disease (PD), 10 patients with Friedreich's ataxia (FA) and 21 patients with epilepsy (EP) who were recruited from the Kirikkale University Neurology Department during 2012 were included in this prospective study. Five groups of age and sex-matched subjects were selected as controls. Corneal sensitivity was measured using a Cochet-Bonnet esthesiometer. Tear function tests included tear break-up time (TBUT) and Schirmer's 1 tests. Results: Compared to their controls, mean corneal sensitivity was significantly reduced in AD, MS, PD and EP patients (all p<0.05), mean TBUT level was significantly shorter in patients with AD and MS (all p<0.05) and mean Schirmer's 1 test score was significantly lower in EP patients (p<0.05). When all groups were compared with each other, reduction of mean corneal sensitivity in AD and PD groups were significantly more than in FA and MS groups (overall p = 0.034). Mean TBUT levels in AD, MS and PD groups were significantly shorter than in FA and EP groups (overall p = 0.001). Mean Schirmer's 1 test scores in AD and PD groups were significantly lower than in MS, FA and EP groups (overall p = 0.040). Conclusions: Neurodegenerative diseases may be associated with reduced corneal sensitivity and abnormal tear function.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.3109/02713683.2014.930154
dc.identifier.endpage428en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue4en_US
dc.identifier.pmid24955505
dc.identifier.scopus2-s2.0-84925293077
dc.identifier.scopusqualityQ1
dc.identifier.startpage423en_US
dc.identifier.urihttps://doi.org/10.3109/02713683.2014.930154
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6195
dc.identifier.volume40en_US
dc.identifier.wosWOS:000351454800008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCurrent Eye Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCorneal sensitivityen_US
dc.subjectneurodegenerative diseasesen_US
dc.subjecttear functionen_US
dc.titleCorneal Sensitivity and Tear Function in Neurodegenerative Diseasesen_US
dc.typeArticle

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