Effects of Topical Phenytoin on Nasal Wound Healing After Mechanical Trauma: An Experimental Study

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dc.contributor.authorSimsek, Gokce
dc.contributor.authorCiftci, Osman
dc.contributor.authorKaradag, Nese
dc.contributor.authorKaratas, Erkan
dc.contributor.authorKizilay, Ahmet
dc.date.accessioned2020-06-25T18:07:55Z
dc.date.available2020-06-25T18:07:55Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionSIMSEK, GOKCE/0000-0001-5281-0986; Ciftci, Osman/0000-0001-5755-3560; kizilay, ahmet/0000-0003-3048-6489
dc.description.abstractObjectives/HypothesisImpaired postoperative wound healing is the second most common morbidity after synechia formation in endoscopic sinus surgery. The aim of this experimental study was to investigate the potential effects of topical phenytoin on wound healing after nasal mucosal trauma in rats. Study DesignAn experimental study at the Inonu University Faculty of Medicine. MethodsTwenty-four rats were randomized into three groups: 1) phenytoin group (n=8), 2) control group (n=8), and 3) vehicle group (n=8). After damaging the right nasal cavity, in the phenytoin group, 1% topical phenytoin cream was applied for 7 days. The rats in the control group did not receive any treatment. The vehicle group was treated with daily topical cold cream for 1 week. The rats were sacrificed at the end, and the nasal cavities were excised. Tissue edema and inflammatory cell infiltration were compared among the groups. Additionally, proliferating cell nuclear antigen (PCNA) and cluster of differentiation 31 (CD31) immunoexpression levels were evaluated. Furthermore, in biochemical analysis, the tissue levels of vascular endothelial growth factor and (EGF) of the groups were investigated. ResultsIn the phenytoin group, tissue edema and inflammatory cell infiltration were significantly decreased, and PCNA and CD31 immunoexpression levels were more prominent (P<.001) and the tissue EGF levels were significantly higher (P<.01). ConclusionsTopical phenytoin treatment may alter the nasal wound healing after mechanical trauma. The potential beneficial effects of topical phenytoin on nasal mucosa should be investigated by further experimental and human trials. Level of EvidenceNA Laryngoscope, 124:E449-E454, 2014en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/lary.24811
dc.identifier.endpageE454en_US
dc.identifier.issn0023-852X
dc.identifier.issn1531-4995
dc.identifier.issue12en_US
dc.identifier.pmid24978057
dc.identifier.scopus2-s2.0-84912534319
dc.identifier.scopusqualityQ1
dc.identifier.startpageE449en_US
dc.identifier.urihttps://doi.org/10.1002/lary.24811
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5692
dc.identifier.volume124en_US
dc.identifier.wosWOS:000345344200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofLaryngoscope
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNasal mucosaen_US
dc.subjectwound healingen_US
dc.subjectphenytoinen_US
dc.subjectintranasal administrationen_US
dc.subjectepidermal growth factoren_US
dc.subjectvascular endothelial growth factoren_US
dc.subjectproliferating cell nuclear antigenen_US
dc.subjectcluster of differentiation 31en_US
dc.subjectratsen_US
dc.subjectanimal experimentationen_US
dc.titleEffects of Topical Phenytoin on Nasal Wound Healing After Mechanical Trauma: An Experimental Studyen_US
dc.typeArticle

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