The Role of Platelet-Derived Growth Factor in the Pathogenesis of Sinonasal Polyps: Immunohistochemical Assessment in Epithelial, Subepithelial and Deep Layers of the Mucosa

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dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorArikan, Osman Kursat
dc.contributor.authorAtasoy, Pinar
dc.contributor.authorKilic, Rahmi
dc.contributor.authorYalcinozan, Eda Tuna
dc.date.accessioned2020-06-25T18:07:05Z
dc.date.available2020-06-25T18:07:05Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives:The aim of this study is to investigate the role of platelet-derived growth factor (PDGF) in the pathogenesis of sinonasal polyps. Methods. Study group (groups 1-3) consisted of nasal polyp samples of patients with sinonasal polyps and the control group consisted of inferior turbinate samples of patients without nasal polyp. In group 1, 14 specimens from ethmoid sinus; in group 2,10 specimens from nasal cavity; in group 3,10 specimens from maxillary sinus; and in group 4 (control), 9 specimens from inferior turbinate were included. By immunohistochemical staining technique, the PDGF positivity index (PI) in mucosal layers and in the inflammatory cells were assessed at the epithelium (EP), subepithelial layer of lamina propria (SE), and deep paraglandular layer of the mucosa (D). Results. Polymorphonudear cell (PMNC)-percentage (%) values of ethmoid and maxillary sinus, and the PDGF PI from all cells of ethmoid sinus and nasal cavity were significantly higher than those of the control group. As mononuclear cell-% (MNC-%) increased, the PDGF_EP_basal PI, PDGF_SE_endothelial PI, and PDGF_D_endothelial PI decreased. As PMNC-PDGF PI increased, the PDGF_D_perivascular PI decreased and PDGF_D_endothelial PI increased. As PDGF-MNC PI increased, the PDGF_EP_apical PI, PDGF_SE_endothelial PI, and PDGF_D_endothelial PI decreased. As PDGF-all cells (PMNCs, MNCs, and fibroblasts) PI increased, the PDGF_EP_basal PI and PDGF_D_endothelial PI decreased, and the PDGF_D_perivascular PI increased. Conclusion. We concluded that the PDGF systems play important roles in polyp pathogenesis. Fibroblast-derived PDGF may be more important than MNC-derived PDGF in polyp developing process. Increased perivascular-PDGF-PI in deep layers of the mucosa may result in sinonasal polyp formation by causing an increase in vascular permeability and extracellular edema, and thus promoting migration of inflammatory cells to extracellular area. Tissue oxygenization may be important for the initiation of PDGF release system. Because of this reason, nasal obstruction should be medically treated earlier, and, if necessary, by surgical approaches.en_US
dc.description.sponsorshipKirikkale University Scientific Research Projects Unit FundsKirikkale Universityen_US
dc.description.sponsorshipThis study was supported by "Kirikkale University Scientific Research Projects Unit Funds."en_US
dc.identifier.citationBayar Muluk, N., Arıkan, O. K., Atasoy, P., Kılıç, R., & Tuna Yalçinozan, E. (2013). The role of platelet-derived growth factor in the pathogenesis of sinonasal polyps: immunohistochemical assessment in epithelial, subepithelial and deep layers of the mucosa. Clinical and experimental otorhinolaryngology, 6(3), 152–160.en_US
dc.identifier.doi10.3342/ceo.2013.6.3.152
dc.identifier.endpage160en_US
dc.identifier.issn1976-8710
dc.identifier.issn2005-0720
dc.identifier.issue3en_US
dc.identifier.pmid24069518
dc.identifier.startpage152en_US
dc.identifier.urihttps://doi.org/10.3342/ceo.2013.6.3.152
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5469
dc.identifier.volume6en_US
dc.identifier.wosWOS:000325040300006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKorean Soc Otorhinolaryngolen_US
dc.relation.ispartofClinical And Experimental Otorhinolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSinonasal polypen_US
dc.subjectPathogenesisen_US
dc.subjectPlatelet-derived growth factoren_US
dc.subjectPerivascularen_US
dc.subjectEndothelialen_US
dc.titleThe Role of Platelet-Derived Growth Factor in the Pathogenesis of Sinonasal Polyps: Immunohistochemical Assessment in Epithelial, Subepithelial and Deep Layers of the Mucosaen_US
dc.typeArticle

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