Role of simple inflammatory parameters in predicting the severity of coronary artery disease

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dc.authoridAydin, Cihan/0000-0002-1401-5727
dc.contributor.authorAydin, Cihan
dc.contributor.authorUyan, Umut
dc.contributor.authorKaradeniz, Muhammed
dc.contributor.authorDemirkiran, Aykut
dc.date.accessioned2025-01-21T16:44:18Z
dc.date.available2025-01-21T16:44:18Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractOBJECTIVE: In our study, we aimed to find simple, useful biomarkers in patients with non-ST elevation myocardial infarction to predict coronary artery severity.METHODS: Between May 2022 and December 2022, patients diagnosed with non-ST elevation myocardial infarction according to the European cardiology guidelines were included in our study. The Synergy between PCI with Taxus and Cardiac Surgery score was calculated to determine the severity of coronary artery disease. These patients were classified into two groups according to Synergy between PCI with Taxus and Cardiac Surgery >= 23 and Synergy between PCI with Taxus and Cardiac Surgery<23 scores. Biochemical markers such as platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio were studied in blood tests taken before coronary angiography in patients diagnosed with non-ST elevation myocardial infarction according to current guidelines. These two groups were compared in terms of the data obtained.RESULTS: There were 281 patients in group 1 and 67 patients in group 2. There was no significant difference between the two groups in terms of demographic data such as age and gender. Platelet-to-lymphocyte ratio [group 1=125 (26-134) and group 2=156 (73-293); p=0.001] and neutrophil-to-lymphocyte ratio [group 1=2.71 (1.3-30.2) and group 2=3.2 (2.1-32.1); p=0.002] were higher in the group of patients with a Synergy between PCI with Taxus and Cardiac Surgery score of <23, while lymphocyte-to-monocyte ratio [group 1=3.6 (0.56-11) and group 2=3.4 (0.64-5.75); p=0.017] was lower in group 2.CONCLUSION: We observed that elevated platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios showed coronary artery severity. Multivessel disease and chronic total occlusion rates were observed to be higher in patients with high platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios.
dc.identifier.doi10.1590/1806-9282.20230518
dc.identifier.issn0104-4230
dc.identifier.issn1806-9282
dc.identifier.issue11
dc.identifier.pmid37820166
dc.identifier.scopus2-s2.0-85175660295
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20230518
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25418
dc.identifier.volume69
dc.identifier.wosWOS:001085313700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssoc Medica Brasileira
dc.relation.ispartofRevista Da Associacao Medica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectNon-ST elevated myocardial infarction; Coronary artery disease; Inflammation; platelets
dc.titleRole of simple inflammatory parameters in predicting the severity of coronary artery disease
dc.typeArticle

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