Effect of alprostadil on erythrocyte deformability in ischemia reperfusion injury

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dc.contributor.authorKara, H.
dc.contributor.authorOzer, A.
dc.contributor.authorArpaci, H.
dc.contributor.authorDemirtas, H.
dc.contributor.authorComu, F. M.
dc.contributor.authorOktar, G. L.
dc.contributor.authorArslan, M.
dc.date.accessioned2020-06-25T18:15:48Z
dc.date.available2020-06-25T18:15:48Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063
dc.description.abstractBACKGROUND: Ischemia reperfusion injury (I/R) in lower extremity is a frequent and important clinical phenomenon. Protective effect of alprostadil on local and distant organ injury due to I/R has been well-documented but its effect on erythrocyte deformability needs further investigation. Our aim was to investigate the effect of alprostadil on erythrocyte deformability in infrarenal aorta of rats undergoing I/R. MATERIALS AND METHODS: Our study was conducted with 18 Wistar albino rats. Rats were divided into 3 groups; randomized control group (group C; n = 6), I/R group without alprostadil (group I/R; n = 6) and I/R group with alprostadil 20 mcg.kg(-1), intraperitoneal (group IR-A; n = 6). Packs of erythrocytes were prepared from heparinized blood samples and deformability measurements were done. RESULTS: Comparisons of the control and IR-A groups revealed similar results (p = 0.240). The values of the IR group were significantly higher than those of the control and IR-A groups (p = 0.009, p = 0.026, respectively). CONCLUSION: In our study, we detected unfavourable effects of I/R on erythrocyte deformability, which may lead to disturbance in blood flow and hence tissue perfusion in infrarenal rat aorta. We also found that alprostadil had beneficial effects by reversing undesirable effects of I/R (Fig. 1, Ref. 22). Text in PDF www.elis.sk.en_US
dc.identifier.citationKara, H., Ozer, A., Arpaci, H., Demirtas, H., Comu, F. M., Oktar, G. L., Erer, D., Kucuk, A., & Arslan, M. (2015). Effect of alprostadil on erythrocyte deformability in ischemia reperfusion injury. Bratislavske lekarske listy, 116(8), 509–511.en_US
dc.identifier.doi10.4149/BLL_2015_099
dc.identifier.endpage511en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue8en_US
dc.identifier.pmid26350094
dc.identifier.scopus2-s2.0-84962207944
dc.identifier.scopusqualityQ2
dc.identifier.startpage509en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2015_099
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6291
dc.identifier.volume116en_US
dc.identifier.wosWOS:000361083000012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecterythrocyte deformabilityen_US
dc.subjectischemia reperfusionen_US
dc.subjectalprostadilen_US
dc.subjectraten_US
dc.titleEffect of alprostadil on erythrocyte deformability in ischemia reperfusion injuryen_US
dc.typeArticle

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