Impact of medium cut-off membranes on S100A12 and soluble receptor for advanced glycation end products

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dc.authoridYETER, hasan haci/0000-0002-5787-1048
dc.authoridKorucu, Berfu/0000-0002-0597-5822
dc.contributor.authorKorucu, Berfu
dc.contributor.authorYeter, Hasan
dc.contributor.authorGonen, Sevim
dc.contributor.authorDerici, Mehmet Kursat
dc.contributor.authorRonco, Claudio
dc.contributor.authorDerici, Ulver
dc.date.accessioned2025-01-21T16:41:41Z
dc.date.available2025-01-21T16:41:41Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIntroduction Of the most remarkable molecules associated with atherosclerosis and the cardiovascular outcome are S100A12 (10,379.5 Da) and soluble receptor for advanced glycation end products (sRAGE-42,803 Da) in the hemodialysis (HD) population. We designed a study investigating the effects of the medium cut-off (MCO) dialyzers focusing on S100A12 and sRAGE in HD patients compared with low-flux and high-flux dialyzers. Methods This single-site, prospective, observational study comprises age and sex-matched HD groups (low-flux, high-flux, and MCO). Blood samples were drawn at baseline (predialysis and postdialysis) and the sixth month (predialysis). Results Groups had similar demographic features and laboratory parameters. Baseline S100A12 levels of the groups were similar [34.3 (+/- 66.5), 30.9 (+/- 42.7), and 40.6 (+/- 29.6); p = 0.13]. Compared to their baseline, the sixth-month S100A12 levels were constant in low-flux and high-flux group and significantly lower in MCO group (p = 0.16, p = 0.33, and p = 0.004). Baseline sRAGE levels of the groups were similar at baseline [2.8 (+/- 0.8), 2.7 (+/- 0.6), and 2.6 (+/- 0.7); p = 0.65], and the sixth-month [2.9 (+/- 0.5), 2.4 (+/- 0.7), and 2.4 (+/- 0.8); p = 0.24]. sRAGE levels remained constant in all groups [p = 0.84, p = 0.13, and p = 0.39]. S100A12/sRAGE ratio at baseline and sixth month was constant in low-flux [22.3 (+/- 63.7) and 18.1 (+/- 24.8); p = 0.17] and high-flux groups [11.9 (+/- 15.3) and 13.1 (+/- 5.8); p = 0.26], the ratio decreased significantly in MCO group [16.5 (+/- 11.6) to 7.8 (+/- 5.5); p = 0.03]. Conclusion Our study suggests that prolonged use of MCO dialyzers is associated with better S100A12 and sRAGE levels. Long-term studies with larger samples are needed to understand the effects of a better S100A12-sRAGE profile provided by MCO dialyzers on HD patients' cardiovascular outcomes.
dc.description.sponsorshipTurkish Hypertension and Kidney Diseases Association
dc.description.sponsorshipThe study expenditures were sponsored by the Turkish Hypertension and Kidney Diseases Association.
dc.identifier.doi10.1111/sdi.13107
dc.identifier.endpage200
dc.identifier.issn0894-0959
dc.identifier.issn1525-139X
dc.identifier.issue3
dc.identifier.pmid35686486
dc.identifier.scopus2-s2.0-85131551649
dc.identifier.scopusqualityQ3
dc.identifier.startpage193
dc.identifier.urihttps://doi.org/10.1111/sdi.13107
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24919
dc.identifier.volume36
dc.identifier.wosWOS:000808436700001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofSeminars In Dialysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.titleImpact of medium cut-off membranes on S100A12 and soluble receptor for advanced glycation end products
dc.typeArticle

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