Enterotoxigenic Escherichia coli: Scientific letter

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dc.contributor.authorAbut, Latife İşeri
dc.date.accessioned2020-06-25T17:43:38Z
dc.date.available2020-06-25T17:43:38Z
dc.date.issued2007
dc.description.abstractEnterotoxigenic Esherichia coli (ETEC) is a major cause of diarrhea in infants and tourists in underdeveloped countries. It is transmitted by ingestion of contaminated food and water. Enterotoxigenic E. coli produces a heat-labile toxin (LT) and a heat-stable toxin (ST). The genes of these toxins are encoded by plasmids. The disease requires colonization of bacteria and elaboration of one or more enterotoxins. The bacteria colonize the gastrointestinal tract by means of a fimbrial adhesin, i.e. colonization factor Antigen I and II (CFA I and CFA II). ETEC is a noninvasive pathogen. The LT enterotoxin is very similar to cholera toxin. It binds to the same intestinal receptors. Enzymatic activity of LT is identical to that of the cholera toxin. While LT causes an increase in cyclic AMP in the host cell, ST increases cyclic GMP levels in the host cell cytoplasm. Cellular cyclic AMP and GMP lead to increased secretion of electrolytes and fluid, which results with diarrhea without fever. ETEC infection is diagnosed by determination of toxins in stool samples. Oral rehydration therapy is often lifesaving in children. Most patients recover with appropriate supportive therapy. Antibiotics are usually not required. ETEC infection can be prevented by avoiding foods and beverages that may be contaminated with bacteria. Adults in endemic areas evidently develop immunity. Toxin- and CFA-based vaccines are the major tools for immunization.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage773en_US
dc.identifier.issn1300-0292
dc.identifier.issn2146-9040
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-37049017420
dc.identifier.scopusqualityQ4
dc.identifier.startpage768en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3835
dc.identifier.volume27en_US
dc.identifier.wosWOS:000254582800019
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isotr
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEscherichia colien_US
dc.subjectescherichia coli infectionsen_US
dc.subjectenterotoxin LTen_US
dc.subjectheat stable toxin (E.coli)en_US
dc.titleEnterotoxigenic Escherichia coli: Scientific letteren_US
dc.typeArticle

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