Zinc Ameliorates Nogo-A Receptor and Osteocalcin Gene Expression in Memory-Sensitive Rat Hippocampus Impaired by Intracerebroventricular Injection of Streptozotocin

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dc.authoridGumus, Haluk/0000-0001-7689-7131
dc.authoridBALTACI, SALTUK BUGRA/0000-0002-9752-7508
dc.contributor.authorGumus, Haluk
dc.contributor.authorBaltaci, Saltuk Bugra
dc.contributor.authorUnal, Omer
dc.contributor.authorGulbahce-Mutlu, Elif
dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.date.accessioned2025-01-21T16:55:59Z
dc.date.available2025-01-21T16:55:59Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractMetabolic dysfunction is a critical step in the etiopathogenesis of Alzheimer's disease. In this progressive neurological disorder, impaired zinc homeostasis has a key role that needs to be clarified. The aim of this study was to investigate the effect of zinc deficiency and administration on hippocampal Nogo-A receptor and osteocalcin gene expression in rats injected with intracerebroventricular streptozotocin (icv-STZ). Forty male Wistar rats were divided into 5 groups in equal numbers: Sham 1 group received icy artificial cerebrospinal fluid (aCSF); Sham 2 group received icy a CSF and i.p. saline; STZ group received 3 mg/kg icy STZ; STZ-Zn-deficient group received 3 mg/kg icy STZ and fed a zinc-deprived diet; STZ-Zn-supplemented group received 3 mg/kg icy STZ and i.p. zinc sulfate (5 mg/kg/day). Hippocampus tissue samples were taken following the cervical dislocation of the animals under general anesthesia. Nogo-A receptor and osteocalcin gene expression levels were determined by real-time-PCR method. Zinc supplementation attenuated the increase in hippocampal Nogo-A receptor gene expression, which was significantly increased in zinc deficiency. Again, zinc supplementation upregulated the intrinsic protective mechanisms of the brain by activating osteocalcin-expressing cells in the brain. The results of the study show that zinc has critical effects on Nogo-A receptor gene expression and hippocampal osteocalcin gene expression levels in the memory-sensitive rat hippocampus that is impaired by icv-STZ injection. These results are the first to examine the effect of zinc deficiency and supplementation on hippocampal Nogo-A receptor and osteocalcin gene expression in icv-STZ injection in rats.
dc.description.sponsorshipScientific Research Projects Coordinatorship of Selcuk University [19102046]
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordinatorship of Selcuk University (SUBAPK; project no. 19102046).
dc.identifier.doi10.1007/s12011-022-03410-4
dc.identifier.endpage3386
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue7
dc.identifier.pmid36057764
dc.identifier.scopus2-s2.0-85137435219
dc.identifier.scopusqualityQ1
dc.identifier.startpage3381
dc.identifier.urihttps://doi.org/10.1007/s12011-022-03410-4
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25882
dc.identifier.volume201
dc.identifier.wosWOS:000849482800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectIcv-STZ injection; Zinc; Hippocampus; Nogo-A receptor; Osteocalcin
dc.titleZinc Ameliorates Nogo-A Receptor and Osteocalcin Gene Expression in Memory-Sensitive Rat Hippocampus Impaired by Intracerebroventricular Injection of Streptozotocin
dc.typeArticle

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