Protective Effects of Methotrexate and Tenoxicam in Peridural Fibrosis in Rat Laminectomy Model

Basit Öğe Kaydı
dc.contributor.authorKasimcan, Omur
dc.contributor.authorKaptan, Hulagu
dc.contributor.authorAktas, Savas
dc.contributor.authorBakar, Bulent
dc.contributor.authorKarabagli, Hakan
dc.date.accessioned2020-06-25T18:15:47Z
dc.date.available2020-06-25T18:15:47Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: Peridural fibrosis after laminectomy is an important surgical problem. Tenoxicam is a nonsteroidal antiinflammatory drug and an oxicam derivative acting by inhibiting the formation of prostaglandin and eicosanoids. Low dose methotrexate which has been used as an antiinflammatory agent rhomatoid arthritis inhibits the synthesis of potentially toxic compounds those accumulate in inflamed tissues. The aim of this study was to evaluate and compare the efficacy of these two independent pharmacological agents in the inhibition of peridural fibrosis. Methods: L3-4-5 bilateral laminectomy with sparing the dura mater integrity was perfomed to 30 male Wistar albino rats. Except the SHAM group, low dose methotraxate (0.2 mg/kg) or tenoxicam (0.5 mg/kg) was administered on the dura mater before the surgical closure. After 42 days, all rats were euthanized and their spinal columns performed laminectomy were removed for the histopathological evaluation. Results: The peridural fibrosis grades of the groups administered low dose methotrexate or tenoxicam were lower than SHAM group grades. They have lower fibroblast counts than SHAM group numerically, although there was no statistically significant difference among groups. Conclusion: Local usage of low dose methotrexate and tenoxicam may be helpful option for prevention of peridural fibrosis after laminectomy procedures in future.en_US
dc.identifier.citationKasımcan M., Kaptan H., Aktaş S., Bakar B., Karabağlı H., (2015). Protective Effects of Methotrexate and Tenoxicam in Peridural Fibrosis in Rat Laminectomy Model. Journal of Neurological Sciences (Turkish), 32(3), 528 - 538.en_US
dc.identifier.endpage538en_US
dc.identifier.issn1302-1664
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84944204826
dc.identifier.scopusqualityN/A
dc.identifier.startpage528en_US
dc.identifier.trdizinid183518
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6279
dc.identifier.volume32en_US
dc.identifier.wosWOS:000365428100007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherJournal Neurological Sciencesen_US
dc.relation.ispartofJournal Of Neurological Sciences-Turkish
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPeridural fibrosisen_US
dc.subjectlaminectomyen_US
dc.subjectmethotraxateen_US
dc.subjecttenoxicamen_US
dc.titleProtective Effects of Methotrexate and Tenoxicam in Peridural Fibrosis in Rat Laminectomy Modelen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Protective Effects of Methotrexate and Tenoxicam in Peridural Fibrosis in Rat Laminectomy Model.pdf
Boyut:
313.08 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu