The Potential Protective Effects of 2-aminoethyl Diphenylborinate against Inner Ear Acoustic Trauma: Experimental Study Using Transmission and Scanning Electron Microscopy

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dc.contributor.authorKaymakci, Mustafa
dc.contributor.authorAcar, Mustafa
dc.contributor.authorBurukoglu, Dilek
dc.contributor.authorKutlu, Hatice Mehtap
dc.contributor.authorShojaolsadati, Paria
dc.contributor.authorCingi, Cemal
dc.contributor.authorMuluk, Nuray Bayar
dc.date.accessioned2020-06-25T18:13:21Z
dc.date.available2020-06-25T18:13:21Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionShojaolsadati, Paria/0000-0001-8311-5425
dc.description.abstractOBJECTIVE: In this prospective experimental study, we investigated the preventive effects of 2-aminoethyl diphenylborinate (2-APB) in rats exposed to acoustic trauma (AT). Light microscopic, transmission electron microscopic (TEM), and scanning electron microscopic (SEM) examinations were performed. MATERIALS and METHODS: Eighteen healthy Wistar albino rats were divided into the following three groups: groups 1 (control), 2 (AT), and 3 (AT+APB). The rats in groups 2 and 3 were exposed to AT; in group 3 rats, 2-APB at 2 mg/kg was also administered, initially transperitoneally, after 10 min. RESULTS: During the light microscopic, TEM, and SEM examinations, the structures of the cochlear hair cells, stereocilia, and Deiter's cells were normal in the control group. In the AT group, the organ of Corti and proximate structures were damaged according to the light microscopic examination. During the TEM examination, intense cellular damage and stereocilia loss were detected, while during the SEM examination, extensive damage and stereocilia loss were observed. Decreased damage with preserved cochlear structure was detected during the light microscopic examination in the AT+APB group than in the AT group. During the TEM and SEM examinations, although stereocilia loss occurred in the AT+APB group, near-normal cell, cilia, and tectorial membrane structures were also observed in the AT+APB group compared with the AT group. CONCLUSION: 2-APB may have protective effects against AT damage of the cochlea. The main mechanism underlying this effect is the inhibition of the vasoconstriction of the cochlear spiral modiolar artery, thereby improving cochlear blood flow. We conclude that 2-APB may also be effective if used immediately following AT.en_US
dc.description.sponsorshipContinuous Education and Scientific Research Associationen_US
dc.description.sponsorshipWith the exception of data collection, the preparation of this paper, including design and planning, was supported by the Continuous Education and Scientific Research Association. Only scientific support was provided; no grant or funding was received.en_US
dc.identifier.citationKaymakçi, Mustafa & Acar, Mustafa & Burukoğlu, Dilek & Kutlu, H Mehtap & Shojaolsadati, Paria & Cingi, Cemal & Bayar Muluk, Nuray. (2015). The Potential Protective Effects of 2-aminoethyl Diphenylborinate against Inner Ear Acoustic Trauma: Experimental Study Using Transmission and Scanning Electron Microscopy. The journal of international advanced otology. 11(1), 1-5.en_US
dc.identifier.doi10.5152/iao.2015.752
dc.identifier.endpage5en_US
dc.identifier.issn1308-7649
dc.identifier.issn2148-3817
dc.identifier.issue1en_US
dc.identifier.pmid26223709
dc.identifier.scopus2-s2.0-84941565889
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.5152/iao.2015.752
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6181
dc.identifier.volume11en_US
dc.identifier.wosWOS:000357533000002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAvesen_US
dc.relation.ispartofJournal Of International Advanced Otology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject2-Aminoethyl diphenylborinate (2-APB)en_US
dc.subjectacoustic trauma (AT)en_US
dc.subjectelectron microscopyen_US
dc.titleThe Potential Protective Effects of 2-aminoethyl Diphenylborinate against Inner Ear Acoustic Trauma: Experimental Study Using Transmission and Scanning Electron Microscopyen_US
dc.typeArticle

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