Is there a relationship between the blood cholinesterase and QTc interval in the patients with acute organophosphate poisoning?

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dc.contributor.authorBaydin, A.
dc.contributor.authorAygün, D.
dc.contributor.authorYazici, M.
dc.contributor.authorKarataş, A.
dc.contributor.authorDeniz, T.
dc.contributor.authorYardan, T.
dc.date.accessioned2020-06-25T17:43:46Z
dc.date.available2020-06-25T17:43:46Z
dc.date.issued2007
dc.descriptionBAYDIN, AHMET/0000-0003-4987-0878
dc.description.abstractOrganophosphates cause poisoning as a result of the excessive accumulation of acetylcholine at the cholinergic synapses due to inhibition of acetylcholinesterase (ChE). In the literature, it has been reported that there have been electrocardiographic abnormalities, including QT-interval prolongation in most patients with acute organophosphate poisoning (OPP), and a relation between blood ChE level and clinical severity in acute OPP. The aim of this study is to assess the relationship between blood ChE level and QTc interval in the patients with acute OPP. This retrospective study consists of 20 patients admitted to the emergency intensive care unit. A total of 93 QTc interval and blood ChE measures obtained on the same day from 20 cases were compared for their correlation. There were prolonged QTc intervals in 35.4% of the ECGs. There was a negative correlation between QTc interval and blood ChE measures. In following up the patients with acute OPP, QTc interval may be useful when blood ChE levels are low and may provide complementary information concerning the severity of poisoning. However, further prospective studies, supporting the present results, are needed.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/j.1742-1241.2006.00931.x
dc.identifier.endpage930en_US
dc.identifier.issn1368-5031
dc.identifier.issn1742-1241
dc.identifier.issue6en_US
dc.identifier.pmid17504354
dc.identifier.scopus2-s2.0-34248402782
dc.identifier.scopusqualityQ1
dc.identifier.startpage927en_US
dc.identifier.urihttps://doi.org10.1111/j.1742-1241.2006.00931.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3885
dc.identifier.volume61en_US
dc.identifier.wosWOS:000246429200009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal Of Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleIs there a relationship between the blood cholinesterase and QTc interval in the patients with acute organophosphate poisoning?en_US
dc.typeArticle

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