The Effects of Thymoquinone (Kalonji) on Abdominal Adhesion in Experimental Abdominal Adhesive Model

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dc.contributor.authorOzden, Huseyin
dc.contributor.authorSaygun, Oral
dc.contributor.authorDaphan, Cagatay E.
dc.contributor.authorAydinuraz, Kuzey
dc.contributor.authorAydin, Oktay
dc.contributor.authorTanrikulu, Fatma Benli
dc.contributor.authorDom, Sedat
dc.date.accessioned2021-01-14T18:10:34Z
dc.date.available2021-01-14T18:10:34Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionOzden, Huseyin/0000-0002-2786-3805
dc.description.abstractThe aim of this study was to investigate the effects of thymoquinone on abdominal adhesion development in an experimental abdominal adhesion model. Forty-five female Wistar albino rats weighing 260-280 g were used in the study. The rats were randomized into 3 even groups. Control, serum physiological (SP), and thymoquinone (TQ) groups were formed. In the experimental abdominal adhesion model, caecum serosa was brushed until the petechial hemorrhages were seen. No additional procedures were performed in the control group except surgery protocol. SP was injected over the caecum in the SP group. In the thymoquinone group, the abdomen was closed after the application of prepared thymoquinone solution on the caecum surface. On the 21st day, tissue samples from sacrificed rats were examined macroscopically and microscopically, and statistically evaluated. There was a statistically significant difference between the control group and the thymoquinone group in the microscopic evaluation (p = 0.006). However, there was no statistically significant difference between SP group and control group, and between thymoquinone group and SP group. Macroscopic evaluation revealed a statistically significant difference between the thymoquinone group and the control group, and between the thymoquinone group and the SP group (p = 0.009,p = 0.027, respectively). In the microscopic and macroscopic evaluation, it was observed that thymoquinone had a decreasing effect on postoperative adhesions. We think that this effect of thymoquinone is due to its anti-inflammatory and antioxidant properties. However, the available data are not sufficient for this effect to be used in medical treatment. Further studies are needed in the future.en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1007/s12262-019-01941-0
dc.identifier.endpage309en_US
dc.identifier.issn0972-2068
dc.identifier.issn0973-9793
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85069899654
dc.identifier.scopusqualityQ4
dc.identifier.startpage305en_US
dc.identifier.urihttps://doi.org/10.1007/s12262-019-01941-0
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12680
dc.identifier.volume82en_US
dc.identifier.wosWOS:000550284800023
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSPRINGER INDIAen_US
dc.relation.ispartofINDIAN JOURNAL OF SURGERY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThymoquinoneen_US
dc.subjectAbdominal adhesionen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectAntioxidanten_US
dc.titleThe Effects of Thymoquinone (Kalonji) on Abdominal Adhesion in Experimental Abdominal Adhesive Modelen_US
dc.typeArticle

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