The Effect of Long Term Pre/postnatal Low/high Dose Nicotine Exposure on Tissue Oxidant/antioxidant Status and DNA Damage in Rats

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dc.contributor.authorMizrak, S.
dc.contributor.authorTuran, V.
dc.contributor.authorCaglayan, O.
dc.contributor.authorErcan, G.
dc.date.accessioned2020-06-25T18:13:02Z
dc.date.available2020-06-25T18:13:02Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: Most women do not stop smoking either during pregnancy or in the lactation period. This study was carried out to investigate the effect of long term per oral pre/postnatal low/high dose nicotine exposure on fetal plasma/tissue oxidant-antioxidant status in rats. Methods: The study groups were composed of pups whose parents used or did not use nicotine in pregnancy and lactation period. The pups were divided into 3 groups, each consisting of 10 rats; the control group (normal drinking water), low and high dose nicotine groups according to the dose of nicotine (0.4mg/kg and 6.0mg/kg BW/day, respectively) given per oral in drinking water. At the end of the 12(th) month, tissue/hemolysate/plasma oxidant-antioxidant status parameters and 8-hydroxy-2-deoxy-guanosine levels were measured. Results: Plasma cotinine levels were higher in nicotine groups compared to controls (p<0.01). A significant increase in liver malonyldialdehyde levels (p<0.05) and a significant decrease in kidney superoxide dismutase activities (p<0.05) were determined in both nicotine groups compared to controls while no statistically significant difference was found in the other parameters. Conclusion: This investigation showed that long term nicotine exposure during-after pregnancy may have an adverse effect on vital organs of the offspring via impairing tissue oxidant/antioxidant balance. Liver and kidney seem to be the mostly affected organs possibly due to their major roles in nicotine metabolism.en_US
dc.description.sponsorshipEge University Scientific Research Projects Funding BAP TIP [09TIP020]en_US
dc.description.sponsorshipOur study was supported by Ege University Scientific Research Projects Funding BAP TIP 09TIP020.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1055/s-0034-1387739
dc.identifier.endpage436en_US
dc.identifier.issn2194-9379
dc.identifier.issn2194-9387
dc.identifier.issue8en_US
dc.identifier.pmid25188608
dc.identifier.startpage432en_US
dc.identifier.urihttps://doi.org/10.1055/s-0034-1387739
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6108
dc.identifier.volume65en_US
dc.identifier.wosWOS:000359157000008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofDrug Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnicotineen_US
dc.subjectoxidanten_US
dc.subjectantioxidant statusen_US
dc.subjectMDAen_US
dc.subjectSODen_US
dc.subjectCATen_US
dc.subjectcotinineen_US
dc.subject8-OHdGen_US
dc.subjectraten_US
dc.titleThe Effect of Long Term Pre/postnatal Low/high Dose Nicotine Exposure on Tissue Oxidant/antioxidant Status and DNA Damage in Ratsen_US
dc.typeArticle

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