What is the Combined Effects of Ginkgo Biloba Extract (EGb761) and Acute Exhaustive Exercise on the Thiol-Disulfide Homeostasis in Rats?

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dc.contributor.authorKabakçi, Ruhi
dc.contributor.authorÇinar, Yasemin
dc.contributor.authorÇinar, Miyase
dc.date.accessioned2025-01-21T16:29:04Z
dc.date.available2025-01-21T16:29:04Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThis study aimed to evaluate the alone and combined effects of ginkgo biloba extract (EGb761) and acute exhaustive exercise on thiol-disulfide homeostasis (TDH) in male rats. Four experimental groups were formed with total 32 rats. Animals in the control and exercise groups received 2 mL/kg of 0.9% saline solution 5 days a week for 4 weeks, while the others in the ginkgo biloba and ginkgo biloba plus exercise groups received 100 mg/kg of EGb761 for the same duration. At the end of this period, rats in groups E and GB+E were made to run on a treadmill at 25 m/min at 5% incline until exhaustion. All plasma samples were evaluated for malondialdehyde (MDA) and nitric oxide (NO) levels, superoxide dismutase activity (SOD), and TDH. The findings of the study showed that exercise significantly increased MDA levels (P < .001) and SOD activity (P < .05) in group GB+E, while only MDA levels were decreased significantly (P < .05) in group GB. On the other hand, neither exercise nor EGb761 could affect the NO levels and the parameters related to TDH (P > .05). Although EGb761 can prevent oxidative stress by reducing MDA, its usage in exercise still needs to be further investigated, especially in terms of TDH that is a new important oxidative stress marker. © 2022, Ataturk Universitesi. All rights reserved.
dc.description.sponsorshipKırıkkale University Scientific Research Projects Coordination Unite, (2020/057)
dc.identifier.doi10.5152/VetSciPract.2022.220409
dc.identifier.endpage40
dc.identifier.issn2822-3608
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85169833628
dc.identifier.scopusqualityQ4
dc.identifier.startpage35
dc.identifier.trdizinid1138500
dc.identifier.urihttps://doi.org/10.5152/VetSciPract.2022.220409
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1138500
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23695
dc.identifier.volume17
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAtaturk Universitesi
dc.relation.ispartofVeterinary Sciences and Practices
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectAcute exercise; ginkgo biloba; oxidative stress; thiol-disulfide homeostasis
dc.titleWhat is the Combined Effects of Ginkgo Biloba Extract (EGb761) and Acute Exhaustive Exercise on the Thiol-Disulfide Homeostasis in Rats?
dc.title.alternativeSıçanlardaki Tiyol-Disülfit Dengesi Üzerine Ginkgo Biloba Özü ve Akut Yorucu Egzersizin Birlikte Uygulanmasının Etkileri Nelerdir?
dc.typeArticle

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