The Efficacy of Glucosamine and Chondroitin Sulfate in Osteoarthritis Management: Review
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Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ortadogu Ad Pres & Publ Co
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Osteoarthritis (OA), the most common form of arthritis, has become a public health concern with gradually increasing importance because of the aging of the world population. It is a degenerative joint disease with unknown accurate etiology. OA is a multifactorial process influenced by metabolic, genetic and other risk factors. Recently, increasing number of clinical trials, related to either etiopathogenesis or new therapeutic approaches are remarkable. During this period, the terms "disease modifying osteoarthritis drugs (DMOADs) or condroprotective drugs" came into prominence. Two of the most important members of this group are glucosamine and chondroitin Sulfate. They are natural building blocks of joint cartilage and play important roles in both maintenance and restoration of it. Glucosamine and chondroitin sulfate are classified as food supplements rather than drugs in our country as well as in many other countries. Many commercial forms including these compounds can be obtained by patients without any prescription subsequently leading to misuse. Nevertheless, because of their wide safety profile, they are recommended by many physicians as an adjuvant to standard OA treatment. In this review, in the light of the recent literature within the last ten years, the efficacy and safety of glucosamine and chondroitin sulfate in OA management and their adverse reaction profiles, which rarely occur, were discussed. There are some clinical trials, which have revealed rather conflicting results due to the short span of time, different commercial products and other methodological differences. However, according to the results of multicenter and well-designed clinical trials conducted in the last few years, glucosamine and chondroitin sulfate seem effective in decreasing the intensity of symptoms in moderate to severe OA.
Açıklama
Anahtar Kelimeler
Osteoarthritis, glucosamine, chondroitin
Kaynak
Turkiye Klinikleri Tip Bilimleri Dergisi
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
29
Sayı
6
Künye
closedAccess
