Effects of chronic L-DOPA administration on neurogenic and endothelium-dependent relaxation responses in rabbit corpus cavernosum

Basit Öğe Kaydı
dc.contributor.authorYildirim, Seniz
dc.contributor.authorFincan, Gokce Sevim Ozturk
dc.contributor.authorIsli, Fatma
dc.contributor.authorErcan, Sevim
dc.contributor.authorSarioglu, Yusuf
dc.date.accessioned2020-06-25T18:17:10Z
dc.date.available2020-06-25T18:17:10Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionSARIOGLU, YUSUF/0000-0002-9227-365X; Yildirim, seniz/0000-0001-8038-5796
dc.description.abstractBackground: Dopamine is a crucial central neurotransmitter that plays a fundamental role in the autonomic and somatic components of penile reflexes in animals and humans. Similar to the erectile responses of dopamine, systemic administration of L-DOPA induces yawning and penile erection in some species. The possible effects of L-DOPA on nitric oxide (NO)-dependent and-independent non-adrenergic non-cholinergic (NANC) relaxation responses mediated by electrical field stimulation (EFS) and endothelium-dependent relaxation were investigated in this study. Methods: Thirty-two adult albino male rabbits, in two- and four-week-treatment groups, were divided into three subgroups: control group (saline-injected) (n = 4), 3 mg/kg/day (low dose) L-DOPA-injected groups (n = 6) and 12 mg/kg/day (high dose) L-DOPA-injected groups (n = 6). After the intraperitoneal injection treatments, the corpus cavernosum tissues were placed in organ bath chambers. The EFS-mediated responses, and the concentration-response curve to carbachol, sodium nitroprusside (SNP), sildenafil were assessed. Results: The two-week treatment with high-dose L-DOPA decreased the NO-dependent NANC relaxation responses, while there was no change in the low-dose two- and four-week treatment groups. The NO independent NANC relaxation responses in the two-week groups decreased, and the responses in the four-week groups were unchanged when compared to the controls. The relaxation responses to carbachol showed no differences among all groups except for the high-dose four-week L-DOPA group. The relaxation responses of SNP and sildenafil were increased in all of the treatment groups when compared to the controls. Conclusions: The observed increases in SNP- and sildenafil-induced responses, along with the decreased EFS-mediated responses, suggest increased sensitivity in the NO-signalling pathway following L-DOPA administration. (C) 2016 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Sp. z o.o. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.pharep.2016.04.012
dc.identifier.endpage934en_US
dc.identifier.issn1734-1140
dc.identifier.issue5en_US
dc.identifier.pmid27362769
dc.identifier.scopus2-s2.0-84976417330
dc.identifier.scopusqualityQ1
dc.identifier.startpage926en_US
dc.identifier.urihttps://doi.org/10.1016/j.pharep.2016.04.012
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6712
dc.identifier.volume68en_US
dc.identifier.wosWOS:000384517600009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPolish Acad Sciences Inst Pharmacologyen_US
dc.relation.ispartofPharmacological Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectL-DOPAen_US
dc.subjectCorpus cavernosumen_US
dc.subjectElectrical field stimulation (EFS)en_US
dc.subjectRabbiten_US
dc.subjectPeripheral nervous systemen_US
dc.titleEffects of chronic L-DOPA administration on neurogenic and endothelium-dependent relaxation responses in rabbit corpus cavernosumen_US
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu