Expressions of MMP2, MMP9, and TIMP-1 in the inflammatory cells of nasal polyps: granulocytes, monocytes, and mast cells

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dc.authoridBAYAR MULUK, NURAY/0000-0003-3602-9289
dc.contributor.authorMuluk, N. Bayar
dc.contributor.authorArikan, O. K.
dc.contributor.authorAtasoy, P.
dc.contributor.authorKilic, R.
dc.contributor.authorYalcinozan, E. Tuna
dc.date.accessioned2025-01-21T16:41:07Z
dc.date.available2025-01-21T16:41:07Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractOBJECTIVE: We investigated the role of matrix metalloproteinase-2 (MMP-2) and MMP-9 in nasal polyp (NP) pathogenesis. PATIENTS AND METHODS: In group 1 (n = 24), polyp specimens were obtained from maxillary sinus, ethmoid sinus, and nasal cavity. In group 2 without NP (control) (n = 11), inferior turbinate samples were taken. Inflammatory cell count and MMP2, MMP9 and tissue inhibitor of metalloproteinase-1 ( TIMP-1), positivity indexes (PIs) were evaluated. RESULTS: Granulocyte and mast cell-MMP2 and MMP9-PI were higher than the rate of monocyte-MMP2-PI and monocyte-MMP9-PI, respectively, in the ethmoid sinus, maxillary sinus, and nasal cavity. Mast Cell-TIMP1-PI was higher than the rates of granulocyte-TIMP1-PI and monocyte-TIMP1-PI in the maxillary sinus and was higher than the rate of monocyte-TIMP1-PI in the ethmoid sinus. CONCLUSIONS: Excessive MMP2 and MMP9, compared to TIMP1, are present in granulocytes and mast cells, respectively. With matrix MMPs, the extracellular matrix is destroyed, leading inflammatory cells to pass through, causing polypoid degeneration.
dc.description.sponsorshipKirikkale University Scientific Research Projects Coordination Unit Funds [2009/16]
dc.description.sponsorshipThis study was supported by Kirikkale University Scientific Research Projects Coordination Unit Funds (Date: 2009, No.: 2009/16).
dc.identifier.endpage20
dc.identifier.issn1128-3602
dc.identifier.pmid37350687
dc.identifier.scopus2-s2.0-85162841807
dc.identifier.scopusqualityQ2
dc.identifier.startpage6
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24808
dc.identifier.volume27
dc.identifier.wosWOS:001011478000002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectMatrix metalloproteinase-2 (MMP-2); Matrix metalloproteinase-9 (MMP-9); Tissue inhibitor of metalloproteinase-1 (TIMP-1); Inflammatory cells; Nasal polyp
dc.titleExpressions of MMP2, MMP9, and TIMP-1 in the inflammatory cells of nasal polyps: granulocytes, monocytes, and mast cells
dc.typeArticle

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