Effect of saccharin, a non-nutritive sweeteners, on insulin and blood glucose levels in healthy young men: A crossover trial

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dc.authoridBAYINDIR GUMUS, AYLIN/0000-0002-1311-2429
dc.authoridTUNCER, ESRA/0000-0001-7151-842X
dc.authoridAltuntas Yildiz, Tugba/0000-0001-6647-9630
dc.contributor.authorGumus, Aylin Bayindir
dc.contributor.authorKeser, Alev
dc.contributor.authorTuncer, Esra
dc.contributor.authorYildiz, Tugba Altuntas
dc.contributor.authorBayram, Ilknur Kepenekci
dc.date.accessioned2025-01-21T16:38:01Z
dc.date.available2025-01-21T16:38:01Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground and aims: Artificial sweeteners used instead of sugar were considered as the best alternatives that have no endocrine effects. However, it has recently been suggested that artificial sweeteners may cause impaired metabolic parameters. The hypothesis of the study was there is an association between acute saccharin consumption and both glycemia and insulin response in young healthy adult men. Methods: 9 healthy adult males were included in this study. This study randomly provided participants with preloads as (a)300 ml of water, or 300 ml of water sweetened with (b)75 g of sucrose, (c)240 mg of saccharine (adjusted to the sweetness of 75 g of sucrose) 1 h before a standard breakfast. Results: Compared to mean blood glucose and serum insulin after test drinks consumption, there was only one difference between sucrose and saccharin trials in the 15th minute (117.0 +/- 18.70, 95.4 +/- 5.64 mg/dl respectively, p < 0.05). At the 60th minute, insulin secretion (0.80 +/- 0.27 pg/dl) after the sucrose trial was found significantly higher than the saccharin trial (0.53 +/- 0.09 pg/dl) and water (0.49 +/- 0.06 pg/dl) (p < 0.05). Although at all intervals (except 90th minute), the mean insulin is higher after the saccharin trial compared to the water trial, these were non-statistically significant differences (p > 0.05). Conclusions: Consequently, it was determined that saccharin had no glycemic effect. However, for the effect on serum insulin to be clarified, the long-term effects should be investigated. (c) 2022 Diabetes India. Published by Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.dsx.2022.102500
dc.identifier.issn1871-4021
dc.identifier.issn1878-0334
dc.identifier.issue6
dc.identifier.pmid35598544
dc.identifier.scopus2-s2.0-85130321877
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.dsx.2022.102500
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24587
dc.identifier.volume16
dc.identifier.wosWOS:000809625400011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofDiabetes & Metabolic Syndrome-Clinical Research & Reviews
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectSaccharin intake; Serum insulin levels; Glycemic response; Non-nutritive sweeteners; Artificial sweeteners
dc.titleEffect of saccharin, a non-nutritive sweeteners, on insulin and blood glucose levels in healthy young men: A crossover trial
dc.typeArticle

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