Peripheral and central smell regions in COVID-19 positive patients: an MRI evaluation

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dc.authoridSAYAR, MERVE SEFA/0000-0002-0436-4122
dc.authoridBAYAR MULUK, NURAY/0000-0003-3602-9289
dc.contributor.authorBurulday, Veysel
dc.contributor.authorSayar, Merve Sefa
dc.contributor.authorBayar Muluk, Nuray
dc.date.accessioned2025-01-21T16:43:22Z
dc.date.available2025-01-21T16:43:22Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground Coronaviruses may lead to invasion of the central nervous system. Purpose To investigate the effects of COVID-19 infection on smell using cranial magnetic resonance imaging (MRI). Material and Methods Cranial MRI scans of 23 patients with COVID-19 (patient group [PG]) and 23 healthy controls (HCs) were evaluated. Peripheric (olfactory bulb [OB] volume and olfactory sulcus [OS] depth) and central (insular gyrus and corpus amygdala areas) smell regions were measured. Results Smell loss was present in nine patients (39.1%) in the PG. The means of the disease duration and antiviral treatment were 3.00 +/- 2.35 and 5.65 +/- 1.72 days, respectively. OB volumes of the PG were significantly lower than those of the HCs bilaterally. However, no significant differences were observed between the OS depth, insular gyrus, and corpus amygdala areas of both groups. The left corpus amygdala areas were both increased with the increased disease (P = 0.035, r = 0.442) and treatment durations (P = 0.037, r = 0.438). In the PG, longer treatment duration, increase in C-reactive protein (CRP), lymphocyte count decrease, and positive thoracic computed tomography (CT) involvement were related to OS depth decrease. Right corpus amygdala areas increased in patients with COVID-19 with increased D-dimer values, and thoracic CT involvement was detected. Conclusion COVID-19 disease affects the peripheric smell region of OBs and does not affect the central smell regions of the insular gyrus and corpus amygdala areas. The importance of our study is to detect MRI findings in patients with COVID-19 leading to odor disorders. These findings may help in diagnosing the disease at an early stage.
dc.identifier.doi10.1177/02841851211034043
dc.identifier.endpage1242
dc.identifier.issn0284-1851
dc.identifier.issn1600-0455
dc.identifier.issue9
dc.identifier.pmid34282630
dc.identifier.scopus2-s2.0-85110946694
dc.identifier.scopusqualityQ3
dc.identifier.startpage1233
dc.identifier.urihttps://doi.org/10.1177/02841851211034043
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25254
dc.identifier.volume63
dc.identifier.wosWOS:000680995600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofActa Radiologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectCOVID-19; olfactory bulb volume; olfactory sulcus depth; insular gyrus area; corpus amygdala area
dc.titlePeripheral and central smell regions in COVID-19 positive patients: an MRI evaluation
dc.typeArticle

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