Adverse effect of VEGFR-2 (rs1870377) polymorphism on the clinical course of COVID-19 in females and males in an age-dependent manner

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dc.authoridSAYIN KOCAKAP, Derya Beyza/0000-0002-8100-3216
dc.authoridEkici, Aydanur/0000-0003-1522-6443
dc.authoridSAHIN, OMER/0000-0003-2616-1454
dc.authoridAKSOY, Emel/0000-0001-9536-4322
dc.authoridKALPAKLIOGLU, AYSE FUSUN/0000-0002-6548-6932
dc.contributor.authorKocakap, Derya Beyza Sayin
dc.contributor.authorKaygusuz, Sedat
dc.contributor.authorAksoy, Emel
dc.contributor.authorSahin, Omer
dc.contributor.authorBaccioglu, Ayse
dc.contributor.authorEkici, Aydanur
dc.contributor.authorKalpaklioglu, Ayse Fusun
dc.date.accessioned2025-01-21T16:35:29Z
dc.date.available2025-01-21T16:35:29Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe COVID-19 pandemic has affected people worldwide with varying clinical presentations ranging from mild to severe or fatal, and studies have found that age, gender, and some comorbidities can influence the severity of the disease. It would be valuable to have genetic markers that might help predict the likely outcome of infection. For this objective, genes encoding VEGFR-2 (rs1870377), CCR5D32 (rs333), and TLR3 (rs5743313) were analyzed for polymorphisms in the peripheral blood of 160 COVID-19 patients before COVID-19 vaccine was available in Turkiye. We observed that possession of the VEGFR-2 rs1870377 mutant allele increased the risk of severe/moderate disease in females and subjects >= 65 years of age, but was protective in males <65 years of age. Other significant results were that the CCR5D32 allele was protective against severe disease in subjects >= 65 years of age, while TLR3 rs5743313 polymorphism was found to be protective against severe/moderate illness in males <65 years of age. The VEGFR-2 rs1870377 mutant allele was a risk factor for severe/moderate disease, particularly in females over the age of 65. These findings suggest that genetic polymorphisms have an age-and sex-dependent influence on the severity of COVID-19, and the VEGFR-2 rs1870377 mutant allele could be a potential predictor of disease severity.(c) 2023 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
dc.description.sponsorshipScientific Research Projects Coor-dination Unit of Kirikkale University [2021/070]
dc.description.sponsorshipAcknowledgement This work was supported by Scientific Research Projects Coor-dination Unit of Kirikkale University, project number 2021/070.
dc.identifier.doi10.1016/j.micinf.2023.105188
dc.identifier.issn1286-4579
dc.identifier.issn1769-714X
dc.identifier.issue8
dc.identifier.pmid37499788
dc.identifier.scopus2-s2.0-85173001316
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.micinf.2023.105188
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24139
dc.identifier.volume25
dc.identifier.wosWOS:001135382000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofMicrobes and Infection
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectSARS-CoV-2; VEGFR-2; CCR5; TLR3; Genetic variations
dc.titleAdverse effect of VEGFR-2 (rs1870377) polymorphism on the clinical course of COVID-19 in females and males in an age-dependent manner
dc.typeArticle

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