Poly(sucrose) micro particles preparation and their use as biomaterials

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dc.contributor.authorŞahiner, Nurettin
dc.contributor.authorSagbaş, Selin
dc.contributor.authorTürk, Mustafa
dc.date.accessioned2020-06-25T18:12:14Z
dc.date.available2020-06-25T18:12:14Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionSagbas Suner, Selin/0000-0002-3524-0675; Sahiner, Nurettin/0000-0003-0120-530X
dc.description.abstractCrosslinked p( sucrose) micro particles were synthesized for the first time from sucrose in water-in-oil microemulsion. Using divinyl sulfone (DVS) as crosslinker via reverse micelles of sodium bis(2-ethylhexyl) sulfosuccinate (AOT) p(sucrose) micro particles formed in a single step with very high yield (>90%). The particles have wide size distributions, and negative zeta potential, -27.30 mV, and can be made magnetic field responsive. P(sucrose) particles were shown to be degradable at pHs of 2.5 and 11. Dopamine and gallic acid were used as model drugs for absorption/release studies from p(sucrose) particles. Interestingly, it was shown that p(sucrose) microparticles can be a nutrient for Escherichia coli, and maybe used as a growth medium for other cells, bacteria and organisms. Additionally, the cytotoxic effect of p(sucrose) particles were determined as 26 and 32.5% dead cells against MDA MB-231 cancerous cells and L929 fibroblast cells at 100 ug/ml concentration, respectively. P(sucrose) particles can be safely used for in vivo applications. (C) 2014 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipTurkish Academy of ScienceTurkish Academy of Sciencesen_US
dc.description.sponsorshipN. Sahiner is grateful to the Turkish Academy of Science for partial support under 2008 TUBA-GEBIP program.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.ijbiomac.2014.02.012
dc.identifier.endpage244en_US
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid24583047
dc.identifier.scopus2-s2.0-84900382371
dc.identifier.scopusqualityQ1
dc.identifier.startpage236en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2014.02.012
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5819
dc.identifier.volume66en_US
dc.identifier.wosWOS:000335201900031
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal Of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPoly(sucrose) particleen_US
dc.subjectMicrogel/nanogelen_US
dc.subjectDrug deliveryen_US
dc.titlePoly(sucrose) micro particles preparation and their use as biomaterialsen_US
dc.typeArticle

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