Effectiveness of oxcarbazepine in symptomatic treatment of painful diabetic neuropathy

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dc.contributor.authorErdemoğlu, A. Kemal
dc.contributor.authorVarlıbaş, Ayhan
dc.date.accessioned2020-06-25T17:43:33Z
dc.date.available2020-06-25T17:43:33Z
dc.date.issued2006
dc.description.abstractBackground: Both basic and clinical research has demonstrated that antiepileptic drugs can be effective in alleviating neuropathic pain. It was hypothesized that oxcarbazepine might be effective in reducing the symptoms of painful diabetic neuropathy. Aims: To investigate the long-term efficacy and safety of oxcarbazepine in symptoms of painful diabetic neuropathy. Materials and Methods: This study included thirty-eight painful diabetic neuropathy patients, which were screened with clinical assessment and electrophysiological studies. The efficacy and safety of oxcarbazepine were evaluated according to the changes in pain intensity and social interference subitems scores of Short-form Brief Pain Inventory besides electrophysiological studies at the end of six months of the treatment. Statistical Analysis: The Students t, Mann-Whitney U and Rank Sum test and Chi-square tests were applied to examine variables differences. The level of statistical significance was chosen to be P<0.05. Results: A significant difference was found in all of subitems of pain intensity and social interference at the end of the study according to the baseline scores. Improvement was observed in 52.7%, 63.1%, 55.3% and 63.2% of patients for worst, least, average and pain right now at the end of six months, respectively. Improvement was observed as 60.6%, 63.2%, 52.6%, 60.5%, 68.4% and 63.2% for general activity, mood, walk, work, people relations, sleep and life enjoyment subitems, respectively. None of these patients had any prominent side effect leading to discontinue the treatment. Conclusion: Long-term oxcarbazepine treatment was found to be effective and safe in the symptoms of painful diabetic neuropathy.en_US
dc.identifier.citationErdemoglu, A. K., & Varlibas, A. (2006). Effectiveness of oxcarbazepine in symptomatic treatment of painful diabetic neuropathy. Neurology India, 54(2), 173–177.en_US
dc.identifier.endpage177en_US
dc.identifier.issn0028-3886
dc.identifier.issue2en_US
dc.identifier.pmid16804263
dc.identifier.scopus2-s2.0-33745749953
dc.identifier.scopusqualityQ3
dc.identifier.startpage173en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3785
dc.identifier.volume54en_US
dc.identifier.wosWOS:000239211900012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNeurol Soc Indiaen_US
dc.relation.ispartofNeurology India
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectoxcarbazepineen_US
dc.subjectpainen_US
dc.subjectdiabetes mellitusen_US
dc.subjectneuropathyen_US
dc.subjecttreatmenten_US
dc.subjectbrief pain inventoryen_US
dc.subjectelectrophysiologyen_US
dc.subjectquality of lifeen_US
dc.titleEffectiveness of oxcarbazepine in symptomatic treatment of painful diabetic neuropathyen_US
dc.typeArticle

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