Effect of botulinum-A toxin to cremaster muscle: an experimental study

Basit Öğe Kaydı
dc.contributor.authorCakmak, M.
dc.contributor.authorCaglayan, F.
dc.contributor.authorErdemoglu, A.K.
dc.contributor.authorUlusoy, S.
dc.date.accessioned2020-06-25T17:35:18Z
dc.date.available2020-06-25T17:35:18Z
dc.date.issued2003
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: A controversy exists on the definition, etiology and treatment of the retractile testes. In the present experimental study, we aimed to show the effect of botulinum-A toxin (Botox) on cremasteric muscle of a rat, and whether it may be an alternative to surgical treatment of retractile testis. Methods: Ten Wistar rats were used in the study. By stimulating cremasteric reflex, five compound muscle action potentials (CMAP) of the right and left cremasteric muscles of each rat were recorded using surface electrodes. Intramuscular injection of botulinum-A toxin was done to the right side. Saline was injected to the left cremasteric muscles, and the left side also served as control. CMAP of the cremasteric muscles were recorded 45 days after the injection. Statistical analysis was done using Wilcoxon Signed rank test. Results: Mean CMAP of the right side was 3.25+/-1.39 muV before the injection and 0.44+/-0.25 muV after botulinum-A toxin injection. The difference was statistically significant (p<0.05). Mean CMAP on the left side was 3.48+/-0.32 muV and 3.14+/-1.12 muV at baseline and the end of the study, respectively. The difference was not statistically significant (p>0.05). Conclusion: The botulinum-A toxin paralyzes the cremasteric muscles of the rats. As cremasteric hypertonicity is accepted as one of the reasons for retractile testes, botulinum-A toxin injection to cremasteric muscles may be helpful in diagnosis and may be an alternative to surgical treatment of this pathology in repeated dosages. Long-term evaluation of this paralysis is necessary.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00240-003-0357-7
dc.identifier.endpage354en_US
dc.identifier.issn0300-5623
dc.identifier.issue5en_US
dc.identifier.pmid14574542
dc.identifier.scopus2-s2.0-19244367446
dc.identifier.scopusqualityN/A
dc.identifier.startpage352en_US
dc.identifier.urihttps://doi.org/10.1007/s00240-003-0357-7
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3086
dc.identifier.volume31en_US
dc.identifier.wosWOS:000186082600012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer-Verlagen_US
dc.relation.ispartofUrological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectretractile testisen_US
dc.subjectbotulinum toxinen_US
dc.subjectexperimental studyen_US
dc.subjectEMGen_US
dc.subjectmuscle action potentialen_US
dc.titleEffect of botulinum-A toxin to cremaster muscle: an experimental studyen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Effect of botulinum-A toxin to cremaster muscle an experimental study.pdf
Boyut:
161.87 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu