Does vitamin C prevent the effects of high dose dexmedetomidine on rat erythrocyte deformability?

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dc.contributor.authorKurtipek, O.
dc.contributor.authorComu, F. M.
dc.contributor.authorOzturk, L.
dc.contributor.authorAlkan, M.
dc.contributor.authorPampal, K.
dc.contributor.authorArslan, M.
dc.date.accessioned2020-06-25T18:06:50Z
dc.date.available2020-06-25T18:06:50Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063; PAMPAL, HASAN KUTLUK/0000-0003-4664-391X
dc.description.abstractPurpose: Dexmedetomidine is an anesthetic agent frequently used for sedation at the intensive care units and during general anesthesia. The purpose of our study was to investigate whether vitamin C prevents the effect of high dose dexmedetomidine on erythrocyte deformability in rats. Methods: The study was performed on 21 male rats, with 7 rats in each study groups and the control group. The rats in the study groups were treated with intraperitoneal dexmedetomidine (10 mu g/kg) and intraperitoneal dexmedetomidine plus Vitamin C (ascorbic acid) (100 mg/kg ascorbic acid administered 1 hour before administration of 10 mu g/kg dexmedetomidine), respectively. Intraperitoneal physiological saline was administered in the control group. Erythrocyte packs were prepared using heparinized total blood samples. Deformability measurements were done by erythrocyte suspensions in phosphate buffered saline (PBS) buffer. A constant flow filtrometer system was used to measure erythrocyte deformability and the relative resistance was calculated. Results: Erythrocyte deformability was significantly higher in dexmedetomidine group than in control and vitamin C plus dexmedetomidine groups (p=0.003, p=0.013, respectively). Erythrocyte deformability indexes were found similar in the control group and in the vitamin C plus dexmedetomidine group (p=0.383) Conclusions: High dose dexmedetomidine may cause functional deterioration in blood flow and tissue perfusion with negative effects in erythrocyte deformability. Vitamin C supplementation seems to reverse those negative effects and variations in erythrocyte deformability. However, our preliminary results should be confirmed in wider serious of experimental and clinical trials (Fig. 1, Ref. 27). Full Text in PDF www.elis.sk.en_US
dc.identifier.citationKurtipek, O., Comu, F. M., Ozturk, L., Alkan, M., Pampal, K., & Arslan, M. (2012). Does vitamin C prevent the effects of high dose dexmedetomidine on rat erythrocyte deformability?. Bratislavske lekarske listy, 113(3), 135–138.en_US
dc.identifier.doi10.4149/BLL_2012_033
dc.identifier.endpage138en_US
dc.identifier.issn0006-9248
dc.identifier.issue3en_US
dc.identifier.pmid22428760
dc.identifier.scopus2-s2.0-84871817516
dc.identifier.scopusqualityQ2
dc.identifier.startpage135en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2012_033
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5374
dc.identifier.volume113en_US
dc.identifier.wosWOS:000302385900002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecterythrocyte deformabilityen_US
dc.subjectalpha(2) agonisten_US
dc.subjectdexmedetomidineen_US
dc.subjectvitamin Cen_US
dc.subjectraten_US
dc.titleDoes vitamin C prevent the effects of high dose dexmedetomidine on rat erythrocyte deformability?en_US
dc.typeArticle

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