Assessment of tebuconazole exposure on bovine testicular cells and epididymal spermatozoa

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dc.authoridKaya, Abdulkadir/0000-0001-7903-4358
dc.authoridYiğit, Ayşe Arzu/0000-0001-5837-6877
dc.authoridKabakci, Ruhi/0000-0001-9131-0933
dc.authoridVarisli, Ömer/0000-0002-2777-3586
dc.contributor.authorKabakci, Ruhi
dc.contributor.authorKaya, Abdulkadir
dc.contributor.authorYiğit, Ayşe Arzu
dc.contributor.authorVarisli, Ömer
dc.date.accessioned2025-01-21T16:36:02Z
dc.date.available2025-01-21T16:36:02Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThis study is the first to investigate the effects of tebuconazole (TEB) on the physiological functions of bovine testicular cells and epididymal spermatozoa. Motility and plasma membrane integrity of spermatozoa exposed to TEB (0.001-100 mM) were evaluated at different incubation times (0-6 h), while TEB-induced spermiotoxicity was assessed after 24 h in cell cultures. Testicular cells, obtained from the parenchyma of bovine testes, were seeded at 1.0 x 10(4) and 1.5 x 10(6) cells/well in 96- and 12-well culture plates and incubated for 48 h in culture media containing TEB (0.001- 100 mM) to evaluate cytotoxicity and hormone release, respectively. TEB did not affect the motility and plasma membrane integrity. However, significant spermiotoxicity occurred at higher TEB (1-100 mM) concentrations (P < 0.05) compared to control and lower doses. Although no dose caused cytotoxicity in testicular cells (P > 0.05), 1 and 100 mM TEB caused a significant increase in testosterone secretion (P < 0.05). As a result, high doses of TEB (1-100 mM) had slightly suppressive effects on spermatozoa; however, these doses had stimulatory effects on testosterone secretion by testicular cells. It appears that the disruption of hormonal homeostasis of testicular cells after TEB exposure may result in metabolic and especially reproductive adverse effects in bulls.
dc.identifier.doi10.1556/004.2021.00023
dc.identifier.endpage188
dc.identifier.issn0236-6290
dc.identifier.issn1588-2705
dc.identifier.issue2
dc.identifier.pmid34214047
dc.identifier.scopus2-s2.0-85113931260
dc.identifier.scopusqualityQ2
dc.identifier.startpage180
dc.identifier.urihttps://doi.org/10.1556/004.2021.00023
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24239
dc.identifier.volume69
dc.identifier.wosWOS:000681019800010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAkademiai Kiado Zrt
dc.relation.ispartofActa Veterinaria Hungarica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectbovine reproduction; fungicide; sperm motility; testis; testosterone synthesis; viability
dc.titleAssessment of tebuconazole exposure on bovine testicular cells and epididymal spermatozoa
dc.typeArticle

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