Comparison of the differences in circadian autonomic function in hyperlipidemic men with and without erectile dysfunction

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dc.contributor.authorDoğru, M. Tolga
dc.contributor.authorBasar, M. Murad
dc.date.accessioned2020-06-25T17:49:16Z
dc.date.available2020-06-25T17:49:16Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground We aimed to investigate differences in circadian autonomic changes in patients suffering from hyperlipidemia with and without erectile dysfunction and compared results to control cases. Materials and methods A total of 77 patients (age range: 24-74, mean age: 45.3 +/- 9.3) with uncontrolled hyperlipidemia (total cholesterol > 200 mg/dL and/or LDL > 160 mg/dL despite a regular diet) were enrolled into the study. These patients were divided into two groups according to their International Index of Erectile Function (IIEF-EF) scores as having erectile dysfunction (IIEF-EF < 26) (Group 1) or as having normal erectile function (IIEF-EF >= 26) (Group 2). In addition, the control group comprised 44 healthy men (age range: 20-57, mean age: 44.0 +/- 10.8) (Group 3). Heart rate variability parameters obtained by 24-h Holter monitoring were utilized for the indirect evaluation of autonomic function. Results There were statistically significant differences between the groups with respect to daytime and nocturnal autonomic activity (p < 0.005). Moreover, Group 1 had lower nocturnal parasympathetic and higher nocturnal sympathetic activity compared to the other groups (for nocturnal HFn p(1-2) < 0.001; p(1-3) < 0.001; p(2-3) > 0.05; for nocturnal LFn p(1-2) < 0.001; p(1-3) < 0.001; p(2-3) > 0.05). Conclusion We concluded that hyperlipidemia results in deterioration of autonomic circadian rhythm. Hyperlipidemic patients with erectile dysfunction had diminished nocturnal parasympathetic activities.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s11255-009-9658-2
dc.identifier.endpage596en_US
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue3en_US
dc.identifier.pmid19866371
dc.identifier.scopus2-s2.0-78549292465
dc.identifier.scopusqualityQ2
dc.identifier.startpage589en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-009-9658-2
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4677
dc.identifier.volume42en_US
dc.identifier.wosWOS:000284910500007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology And Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutonomic nervous systemen_US
dc.subjectErectile dysfunctionen_US
dc.subjectHyperlipidemiaen_US
dc.titleComparison of the differences in circadian autonomic function in hyperlipidemic men with and without erectile dysfunctionen_US
dc.typeArticle

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