The relationship between serum sex steroid levels and heart rate variability parameters in males and the effect of age

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dc.authoridYUVANC, ERCAN/0000-0002-5822-6972
dc.contributor.authorDogru, M. Tolga
dc.contributor.authorBasar, M. Murad
dc.contributor.authorYuvanc, Ercan
dc.contributor.authorSimsek, Vedat
dc.contributor.authorSahin, Omer
dc.date.accessioned2025-01-21T16:33:14Z
dc.date.available2025-01-21T16:33:14Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: We evaluated the relationships between sex steroid levels and heart rate variability (HRV) parameters. Study design: The study included 114 male subjects (mean age 46.6 +/- 11.3 years) presenting to our department for cardiologic evaluation. Hormonal analysis included serum levels of luteinizing hormone, prolactin, total testosterone (TT), free testosterone, estradiol (E2), and dehydroepiandrosterone sulfate (DHEA-S). Parameters of HRV were derived from 24-hour Holter monitoring. The associations between serum sex steroid levels and HRV parameters were investigated in three age groups (20-39 years; 40-59 years; >60 years). Results: All the participants had normal biochemical results. The three age groups were similar in terms of anthropometric measurements. Among sex steroids analyzed, only serum DHEA-S level was significantly different among the groups (p=0.026), showing a decreasing trend with age. In the evaluation of HRV, all parasympathetic activities decreased (for HFn, pNN50, and rMSDD: p=0.001, p=0.000, and p=0.000, respectively), while only LF/HF among sympathetic activities increased (p=0.000) with age. Partial correlation analysis with control of age and waist circumference showed that TT and DHEA-S were positively correlated with HFn (parasympathetic parameter), and were in negative correlation with LF/HF24 hours and global sympathetic index (GSI) (sympathetic parameters). Serum E2 level was negatively correlated with the parasympathetic parameter of rMSSD, and positively correlated with LF/HF24 hours and GSI. Among serum sex steroids, DHEA-S was the most correlated parameter with autonomic functions. Conclusion: Our results showed positive correlations between androgens and parasympathetic activity and between estradiol and sympathetic activity in men, independent from anthropometric factors.
dc.identifier.endpage465
dc.identifier.issn1016-5169
dc.identifier.issue7
dc.identifier.pmid21206198
dc.identifier.scopusqualityQ3
dc.identifier.startpage459
dc.identifier.trdizinid112062
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay112062
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23765
dc.identifier.volume38
dc.identifier.wosWOS:000421514300002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAves
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi-Archives of The Turkish Society of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectAndrogens; dehydroepiandrosterone; electrocardiography; ambulatory; estradiol; gonadal steroid hormones; heart rate; male; testosterone
dc.titleThe relationship between serum sex steroid levels and heart rate variability parameters in males and the effect of age
dc.typeArticle

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