Comparison of a manual walking platform and the CatWalk gait analysis system in a rat osteoarthritis model

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dc.authoridKARA, HALIL/0000-0002-7557-7897
dc.authoridUgurlu, Mahmut/0000-0001-9968-5393
dc.authoridKarahan, Siyami/0000-0002-2744-1717
dc.authoridCaglar, Ceyhun/0000-0003-4286-7852
dc.contributor.authorKara, Halil
dc.contributor.authorCaglar, Ceyhun
dc.contributor.authorAsilturk, Mehmet
dc.contributor.authorKarahan, Siyami
dc.contributor.authorUgurlu, Mahmut
dc.date.accessioned2025-01-21T16:36:44Z
dc.date.available2025-01-21T16:36:44Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground. Effects of osteoarthritis (OA) are observed in experimental animal models using different gait analysis systems. Objectives. The aim of this study was to determine whether the Noldus CatWalk XT v. 10.9 gait analysis sys-tem (CatWalk) device can be used effectively in a chemically induced rat OA model and to reveal the strengths and weaknesses of the system compared to manual gait analysis. Materials and methods. Ten Wistar rats were run on a manual walking platform as well as on the CatWalk and the basal values were recorded. For OA induction, monosodium iodoacetate (MIA) was injected into the left knee of all rats under anesthesia. After a period of 4 weeks for OA development, the rats were again run on both the manual and CatWalk gait platforms. For manual gait analysis, the stride length, paw print width and paw print length were measured on both knees. In addition to these parameters, the average run speed, run duration, maximum contact intensity, paw print area, mean stance, and swing speed were measured on the left knee (affected knee) using the CatWalk device. Results. Significant differences were observed in the stride width (p = 0.0272), left stride length (p = 0.0344), and left paw print length (p = 0.0233) recorded before and after OA via the manual walking platform. For CatWalk, a significant difference was detected in the left knee's average run speed (p = 0.0010), maximum contact intensity (p = 0.0155), paw print length (p = 0.0058), paw print width (p = 0.0324), and swing speed (p = 0.0066) based on data obtained before and after OA. Conclusions. The CatWalk gait analysis system is suitable for the evaluation of OA rat models and related interventions. It also provides additional parameters compared to the manual system and minimizes human-related variation.
dc.identifier.doi10.17219/acem/137536
dc.identifier.endpage956
dc.identifier.issn1899-5276
dc.identifier.issn2451-2680
dc.identifier.issue9
dc.identifier.pmid34387414
dc.identifier.scopus2-s2.0-85113996606
dc.identifier.scopusqualityQ1
dc.identifier.startpage949
dc.identifier.urihttps://doi.org/10.17219/acem/137536
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24376
dc.identifier.volume30
dc.identifier.wosWOS:000704583000009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWroclaw Medical Univ
dc.relation.ispartofAdvances In Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectCatWalk; osteoarthritis; rat model; gait analysis; monosodium iodoacetate
dc.titleComparison of a manual walking platform and the CatWalk gait analysis system in a rat osteoarthritis model
dc.typeArticle

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