Factorial Design Optimization of Solid-Phase Microextraction for High-Performance Liquid Chromatography-Ultraviolet Spectrometry Analysis of Polycyclic Aromatic Hydrocarbons in Cigarette Filter Tar

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dc.contributor.authorDemirci, Ayla
dc.date.accessioned2020-06-25T18:12:15Z
dc.date.available2020-06-25T18:12:15Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.description.abstractA simple and rapid procedure for the determination of polycyclic aromatic hydrocarbons (PAHs) in cigarette filter tar using solid-phase microextraction (SPME) was developed. The analysis was carried out using high-performance liquid chromatography equipped with an ultraviolet detector. The effects of the SPME experimental parameters on the extraction recovery were studied simultaneously using a central composite design (CCD) after a 2(6-2) fractional factorial experimental design. The SPME variables of interest were the extraction temperature, the extraction time, and the stirring speed, as well as the pH and the concentrations of NaCl (%, w/v) and acetonitrile (ACN). The optimal SPME conditions were as follows: an extraction temperature of 65 degrees C, an extraction time of 50min, a stirring speed of 800rpm, 0% NaCl (w/v), 10% ACN in the sample, and a source pH of 8.0. The extraction calibration plots were linear over the range of 0.25-20ng mL(-1) (r(2) > 0.9912) and the limits of detection (LODs) for the 6 PAHs studied were from 0.17-5.02ng cigarette(-1). The relative standard deviation (RSD) ranged from 7.1-13.5% for intra-day variation and from 8.5-18.4% for inter-day variation. The performance of the proposed method was evaluated for extraction and determination PAHs in real samples (various brands of cigarettes). The total amounts of all of the studied PAHs found in the filter tar of the three brands of cigarettes were 320.2, 17.9, and 66.7ng cigarette(-1), respectively.en_US
dc.description.sponsorshipKirikkale University Scientific Research Project Coordination UnitKirikkale Universityen_US
dc.description.sponsorshipThis article was supported by the Kirikkale University Scientific Research Project Coordination Unit.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/10406638.2013.857358
dc.identifier.endpage134en_US
dc.identifier.issn1040-6638
dc.identifier.issn1563-5333
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84897837642
dc.identifier.scopusqualityQ2
dc.identifier.startpage115en_US
dc.identifier.urihttps://doi.org/10.1080/10406638.2013.857358
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5835
dc.identifier.volume34en_US
dc.identifier.wosWOS:000334038800002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPolycyclic Aromatic Compounds
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthigh-performance liquid chromatography- ultraviolet spectrometry (HPLC-UV)en_US
dc.subjectpolycyclic aromatic hydrocarbons (PAHs)en_US
dc.subjectsolid-phase microextraction (SPME)en_US
dc.subjectexperimental designen_US
dc.subjectcigaretteen_US
dc.titleFactorial Design Optimization of Solid-Phase Microextraction for High-Performance Liquid Chromatography-Ultraviolet Spectrometry Analysis of Polycyclic Aromatic Hydrocarbons in Cigarette Filter Taren_US
dc.typeArticle

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