Development of thermo/pH-responsive chitosan coated pectin-graft-poly(N, N-diethyl acrylamide) microcarriers

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dc.contributor.authorIsiklan, Nuran
dc.contributor.authorTokmak, Seyma
dc.date.accessioned2020-06-25T18:30:44Z
dc.date.available2020-06-25T18:30:44Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractPectin based micro/nanocarriers display promising properties for biomedical applications. In this study, thermo/pH-responsive chitosan coated pectin-graft-poly(N,N-diethyl acrylamide) (Pec-g-PDEAAm/CS) microcarriers containing 5-Fluorouracil (5-FU) as a model drug were developed. The structure, thermal stability and surface morphology of 5-FU-loaded microcarriers were investigated using FTIR, XRD, DSC and SEM. Microcarrier formulations were fabricated by varying grafting yield, drug/copolymer ratio, chitosan, and crosslinking agent concentrations. The effect of these parameters on swelling degree and 5-FU release was explored. It was observed that the grafting of pectin with poly(N,N-diethyl acrylamide) ensured sustained/controlled and thermo/pH responsive release of 5-FU. Besides, in vitro cytotoxicity results displayed that Pec-g-PDEAAm/CS microcarriers had good biocompatibility. Results illustrated that 5-FU release and swelling degree of the microcarriers were greatly controlled by especially chitosan shell, 5-FU/copolymer ratio and crosslink density. Therefore, based on the findings the developed thermo/pH-responsive Pec-g-PDEAAm/CS microcarriers might be considered as a promising carrier for controlled drug delivery.en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu or Scientific and Technological Research Council of Turkey TUBITAK; Turkiye (Turkey) [113Z271]en_US
dc.description.sponsorshipThis work was financially supported by the Turkiye Bilimsel ve Teknolojik Arastirma Kurumu or Scientific and Technological Research Council of Turkey TUBITAK. Turkiye (Turkey) with the grant number of 113Z271.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.carbpol.2019.04.068
dc.identifier.endpage125en_US
dc.identifier.issn0144-8617
dc.identifier.issn1879-1344
dc.identifier.pmid31221312
dc.identifier.scopus2-s2.0-85065028082
dc.identifier.scopusqualityQ1
dc.identifier.startpage112en_US
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2019.04.068
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7714
dc.identifier.volume218en_US
dc.identifier.wosWOS:000471864400014
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofCarbohydrate Polymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThermo/pH-responsive microcarrieen_US
dc.subjectPectinen_US
dc.subjectPoly(N, N-diethyl acrylamide)en_US
dc.subject5-Fluorouracilen_US
dc.titleDevelopment of thermo/pH-responsive chitosan coated pectin-graft-poly(N, N-diethyl acrylamide) microcarriersen_US
dc.typeArticle

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