HFE H63D mutation frequency shows an increase in Turkish women with breast cancer

Basit Öğe Kaydı
dc.contributor.authorGünel-Özcan, Ayşen
dc.contributor.authorAlyılmaz-Bekmez, Sibel
dc.contributor.authorGüler, Emine Nilüfer
dc.contributor.authorGüç, Dicle
dc.date.accessioned2020-06-25T17:41:04Z
dc.date.available2020-06-25T17:41:04Z
dc.date.issued2006
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: The hereditary hemochromatosis gene HFE plays a pivotal role in iron homeostasis. The association between cancer and HFE hetero- or homozygosity has previously been shown including hepatocellular and nonhepatocellular malignancies. This study was performed to compare frequencies of HFE C282Y and H63D variants in Turkish women with breast cancer and healthy controls. Methods: Archived DNA samples of Hacettepe University Oncology Institute were used in this study. The HFE gene was investigated by PCR-RFLP. Results: All subjects studied were free from C282Y mutation. Thirty-nine patients had H63D mutation and were all heterozygous. H63D allele frequency was 22.2% (39/176) in the breast cancer patients, and 14% (28/200) in the healthy volunteers. Statistical analysis of cases with HFE H63D phenotype showed significant difference between breast cancer and healthy volunteers ( P = 0.02). Conclusion: Our results suggest that HFE H63D mutation frequencies were increased in the breast cancer patients in comparison to those in the general population. Also, odds ratios ( odds ratio = 2.05) computed in this study suggest that H63D has a positive association with breast cancer.en_US
dc.identifier.citationGunel-Ozcan, A., Alyılmaz-Bekmez, S., Guler, E.N. et al. HFE H63D mutation frequency shows an increase in Turkish women with breast cancer. BMC Cancer 6, 37 (2006). https://doi.org/10.1186/1471-2407-6-37en_US
dc.identifier.doi10.1186/1471-2407-6-37
dc.identifier.issn1471-2407
dc.identifier.pmid16503999
dc.identifier.scopus2-s2.0-33645032772
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/1471-2407-6-37
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3620
dc.identifier.volume6en_US
dc.identifier.wosWOS:000236027000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmcen_US
dc.relation.ispartofBmc Cancer
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleHFE H63D mutation frequency shows an increase in Turkish women with breast canceren_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
HFE H63D mutation frequency shows an increase in Turkish women with breast cancer.pdf
Boyut:
438.66 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu