Effects of feed intake and water hardness on fluralaner pharmacokinetics in layer chickens

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dc.authoridGUNES, Yigit/0000-0002-9403-3545
dc.authoridUSTUN ALKAN, Fulya/0000-0003-1782-9467
dc.authoridANLAS, CEREN/0000-0002-7997-016X
dc.contributor.authorSari, Ataman Bilge
dc.contributor.authorGunes, Yigit
dc.contributor.authorAnlas, Ceren
dc.contributor.authorAlkan, Fulya Ustun
dc.contributor.authorGuncum, Enes
dc.contributor.authorUstuner, Oya
dc.contributor.authorBakirel, Tulay
dc.date.accessioned2025-01-21T16:38:16Z
dc.date.available2025-01-21T16:38:16Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: Fluralaner is a novel drug belonging to the isoxazoline class that acts on external parasites of domestic animals. It is used systemically via drinking water, especially against red poultry mite in layer chickens. Fluralaner is frequently used in layers infected with D. gallinae. However, no study to date has investigated the effects of feed intake and water hardness. Objectives: This study aimed to investigate the effects of variable water hardness and feed intake on the pharmacokinetic profile of fluralaner. Methods: Layer chickens were divided into four groups (n = 8): fed + purified water (Group 1), feed restricted + purified water (Group 2), feed restricted + hard water (Group 3), and feed restricted + soft water (Group 4). After administering a single dose of the drug with drinking water, the blood samples were collected for 21 days. Fluralaner concentrations in plasma samples were determined by liquid chromatography/tandem mass spectrometry. The maximum plasma concentration ( Cmax), time to reach maximum plasma concentration ( tmax), area under the concentration-time curve values (AUC(0-21d)), half-life ( t(1/2)), and other pharmacokinetic parameters were calculated. Results: Although the highest maximum plasma concentration ( C-max) was determined in Group 1 (fed + purified water), no statistically significant difference was found in the C-max, tmax, t(1/2), MRT0- inf_obs, Vz/ F-obs, and Cl/ F-_ obs parameters between the experimental groups. Conclusions: It was concluded that the feed intake or water hardness did not change the pharmacokinetic profile of fluralaner in layer chickens. Therefore, fluralaner could be used before or after feeding with the varying water hardness in poultry industry.
dc.description.sponsorshipScientific Research Projects Unit of Istanbul University-Cerrahpasa [33455]
dc.description.sponsorshipThis study was funded by the Scientific Research Projects Unit of Istanbul University-Cerrahpasa (project No: 33455).
dc.identifier.doi10.4142/jvs.22048
dc.identifier.issn1229-845X
dc.identifier.issn1976-555X
dc.identifier.issue5
dc.identifier.pmid36038185
dc.identifier.scopus2-s2.0-85139379709
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.4142/jvs.22048
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24622
dc.identifier.volume23
dc.identifier.wosWOS:000920484400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKorean Soc Veterinary Science
dc.relation.ispartofJournal of Veterinary Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectIsoxazoles/pharmacokinetics; fluralaner; antiparasitic agents/pharmacokinetics; area under curve; food-drug interactions; poultry; fasting
dc.titleEffects of feed intake and water hardness on fluralaner pharmacokinetics in layer chickens
dc.typeArticle

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