In vivo response to biodegradable controlled antibiotic release systems

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dc.contributor.authorKorkusuz, F.
dc.contributor.authorKorkusuz, P.
dc.contributor.authorEkşioğlu, F.
dc.contributor.authorGürsel, I.
dc.contributor.authorHasirci, V.
dc.date.accessioned2020-06-25T17:34:51Z
dc.date.available2020-06-25T17:34:51Z
dc.date.issued2001
dc.departmentKırıkkale Üniversitesi
dc.descriptionKORKUSUZ, FEZA/0000-0001-9486-3541; Gursel, Ihsan/0000-0003-3761-1166; KORKUSUZ, PETEK/0000-0002-7553-3915
dc.description.abstractIn this study, the major goal was to evaluate in vitro and in vivo findings by macroscopy, radiology, and histology to determine the effectiveness of therapy of experimental implant-related osteomyelitis with antibiotic carrier rods constructed of microbial polyesters. The polymers used were poly(3-hydroxybutyrate-co-4-hydroxyvalerate) [P(3HB-co-4-HB)] and poly(3-hydroxybutyrate-co-3-hydroxy-valerate) [P(3-HB-co-3-HV)]. Both the Sulperazone(R) and the Duocid(R)-P(3-HB-co-4-HB) rods with a drug to polymer ratio of 1:1 (w/w) were effective in treating the bone infection that was experimentally initiated by inoculation of a hemolytic strain of Staphylococcus aureus (coagulase positive; phage type 52/52b) together with metal implants into the medullary area of rabbit tibia. Macroscopical data revealed that the effectiveness of therapy was apparent at week 6 for all categories tested. Radiological findings with Duocid(R)- and Sulperazone(R)-loaded P(3-HB-co-4-HB) rods improved significantly when judged by changes in periosteal elevation, widening of bone shaft, new bone formation, and soft-tissue deformation after 6 weeks of implantation. Histologically the signs of infection were found to subside by weeks 3 and 6. inflammatory cells were replaced with bone-forming cells upon treatment with Sulperazone(R)-P(3-HB-co-4-HB) and Duocid(R)-P(3-HB-co-4-HB). Osteoblastic activity was prominent. Intramedullary inflammation, although still present, started to be replaced by fibrous or bony tissue. Histological findings presented the subsidence of infection. In summary, the antibiotic-loaded biopolymeric rods appeared to have potential as a new controlled-release system for the treatment of implant related osteomyelitis and chronic osteomyelitis. (C) 2001 John Wiley & Sons, Inc.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/1097-4636(200105)55:2<217
dc.identifier.endpage228en_US
dc.identifier.issn0021-9304
dc.identifier.issue2en_US
dc.identifier.pmid11255173
dc.identifier.scopus2-s2.0-0035090112
dc.identifier.scopusqualityN/A
dc.identifier.startpage217en_US
dc.identifier.urihttps://doi.org/10.1002/1097-4636(200105)55:2<217
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2926
dc.identifier.volume55en_US
dc.identifier.wosWOS:000167221200009
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJohn Wiley & Sons Incen_US
dc.relation.ispartofJournal Of Biomedical Materials Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectosteomyelitisen_US
dc.subjectsustained releaseen_US
dc.subjectlocal antiinfective agentsen_US
dc.subjectbiodegradable delivery systemsen_US
dc.subjectpolymersen_US
dc.subjectpoly(hydroxybutyrate-co-hydroxyvalerate)en_US
dc.titleIn vivo response to biodegradable controlled antibiotic release systemsen_US
dc.typeArticle

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