Effect of Dexmedetomidine on Lung Tissue Lower Extremity Ischemia Reperfusion Injury in Streptozotocin Induced Diabetic Rats

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dc.contributor.authorSezen, Saban Cem
dc.contributor.authorCelik, Ilknur Aytekin
dc.contributor.authorAydin, Muhammed Enes
dc.contributor.authorOzterlemez, Naciye Turk
dc.contributor.authorArslan, Mustafa
dc.contributor.authorErbatur, Meral Erdal
dc.contributor.authorKavutcu, Mustafa
dc.date.accessioned2021-01-14T18:11:03Z
dc.date.available2021-01-14T18:11:03Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionCelik, ilknur Aytekin/0000-0003-0754-680X;
dc.description.abstractObjective: The aim of our study was to investigate the effects of dexmedetomidine on lung tissue in rat's lower extremity after undergoing an ischemia reperfusion (I/R) injury. Material and methods: After obtaining ethical committee approval, 24 Wistar albino rats (200-270 gr) were randomly divided into four groups: (Control (Group C), diabetes-control (Group DC), diabetes I/R (Group DIR), and diabetes-I/R-dexmedetomidine (Group DIRD). In diabetes groups, single-dose (55 mg/kg) streptozotocin was administered intraperitoneally. Rats with a blood glucose level above 250 mg/dl at the 72nd hour were accepted as diabetic. At the end of four weeks, laparotomy was performed in all rats. Nothing else was done in Group C and DC. In Group DIR, ischemia reperfusion was produced via two-hour periods of clamping and subsequent declamping of infra-renal abdominal aorta. In Group DIRD, 100 mu g/kg of dexmedetomidine were administered intraperitoneally. Results: When the groups' lung tissue neutrophil infiltration/aggregation light microscopic findings were compared to each other, a significant difference was observed among the groups (p=0.003). When the groups' lung tissue injury score light microscopic findings were compared, a significant difference was observed among the groups (p=0.001). When groups were compared to each other in terms of lung tissue MDA levels and SOD activities, a significant difference was observed (p=0.002, p=0.018, respectively). Conclusion Our results confirm that dexmedetomidine has protective effects against the lung damage resulting from IR in diabetic rats. However, future studies should be conducted to evaluate these effects.en_US
dc.identifier.citationSezen, Ş. C., Aytekin Çelik, İ., Aydın, M. E., Türk Özterlemez, N., Arslan, M., Erdal Erbatur, M., & Kavutçu, M. (2020). Effect of Dexmedetomidine on Lung Tissue Lower Extremity Ischemia Reperfusion Injury in Streptozotocin Induced Diabetic Rats. Gazi Medical Journal, 31(3), 358–362.en_US
dc.identifier.doi10.12996/gmj.2020.87
dc.identifier.endpage362en_US
dc.identifier.issn2147-2092
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85087126282
dc.identifier.scopusqualityQ4
dc.identifier.startpage358en_US
dc.identifier.urihttps://doi.org/10.12996/gmj.2020.87
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12865
dc.identifier.volume31en_US
dc.identifier.wosWOS:000541649000005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGAZI UNIV, FAC MEDen_US
dc.relation.ispartofGAZI MEDICAL JOURNAL
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectischemia reperfusionen_US
dc.subjectlungen_US
dc.subjectraten_US
dc.titleEffect of Dexmedetomidine on Lung Tissue Lower Extremity Ischemia Reperfusion Injury in Streptozotocin Induced Diabetic Ratsen_US
dc.typeArticle

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