Glutathione S-transferase expression in benign and malignant eyelid tumors

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dc.authoridOguztuzun, Serpil/0000-0002-5892-3735
dc.authoridBozer, Busra/0000-0002-7280-4417
dc.contributor.authorSaygin, Efe
dc.contributor.authorKaradag, Remzi
dc.contributor.authorOzkanli, Sidika Seyma
dc.contributor.authorBozer, Busra
dc.contributor.authorOguztuzun, Serpil
dc.contributor.authorAzari, Amir A.
dc.contributor.authorSaygin, Isilay Ozsoy
dc.date.accessioned2025-01-21T16:41:20Z
dc.date.available2025-01-21T16:41:20Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractEyelid tumors commonly originate from the skin and its appendages. Environmental toxins and oxidants affect eyelid carcinogenesis. Glutathione S-transferases (GST) are antioxidants that participate in pathogenesis. We investigated GST levels in malignant and benign eyelid tumors in otherwise healthy individuals. We used 57 malignant eyelid biopsies, benign eyelid biopsies, and tissue removed during blepharoplasty and entropion operations culled from pathology archives. Specimens were divided into three groups: malignant lesions, benign lesions and controls consisting of eyelid tissue removed during routine blepharoplasty and entropion surgery. Specimens were immunostained for seven GST (GST-A, GST-P, GST-Z, GST-S, GST-K, GST-O, GST-T) and the intensity of staining was quantified. In the malignant group, GST-O and GST-P staining was less intense than for the control group. In the benign group, the GST-P level was less than for the control group. We found no significant difference between the intensity of staining in malignant and benign groups. Our findings suggest that GST-O and GST-P enzymes may play significant roles in eyelid carcinogenesis.
dc.description.sponsorshipIstanbul medeniyet universitesi bilimsel arastirma projeleri koordinasyon birimi
dc.description.sponsorshipThis work was supported by Istanbul medeniyet universitesi bilimsel arastirma projeleri koordinasyon birimi.
dc.identifier.doi10.1080/10520295.2021.1986133
dc.identifier.endpage339
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue5
dc.identifier.pmid34696641
dc.identifier.scopus2-s2.0-85118220307
dc.identifier.scopusqualityQ2
dc.identifier.startpage334
dc.identifier.urihttps://doi.org/10.1080/10520295.2021.1986133
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24871
dc.identifier.volume97
dc.identifier.wosWOS:000711256900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectBasal cell carcinoma; carcinogenesis; eyelid tumor; glutathione-S transferase; human; oxidative damage
dc.titleGlutathione S-transferase expression in benign and malignant eyelid tumors
dc.typeArticle

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