Investigation of the Effects of Allicin on the Nasal Mucosa

Basit Öğe Kaydı
dc.authoridBAYAR MULUK, NURAY/0000-0003-3602-9289
dc.authoridArik, Deniz/0000-0003-0905-2731
dc.contributor.authorOzturk, Zeynel
dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorOguz, Oguzhan
dc.contributor.authorPinarbasli, Mehmet Ozgur
dc.contributor.authorGungor, Enes
dc.contributor.authorArik, Deniz
dc.contributor.authorBal, Cengiz
dc.date.accessioned2025-01-21T16:42:12Z
dc.date.available2025-01-21T16:42:12Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: We investigated the effects of allicin on nasal mucosa via an experimental study. Methods: In the study, 16 male New Zealand Albino (2.5-4.5 kg) rabbits were used. The right nasal passages of the 8 rabbits were included in the control group (Group 1, n = 8), and the right nasal passages of the 8 different rabbits were included in the study group (Group 2, n = 8). In the study group (Group 2), a Merocel tampon soaked in Allicin (Alli Tech; Dulwich Health) (0.5 mg/kg). In the control group (Group 1), a Merocel tampon soaked in serum physiologic was placed in the right nasal passage for 3 days (first to third days of the study). On the fourth day, nasal mucosa was excised and histopathological examinations were performed. Results: Our results showed that there were no significant differences in terms of bleeding, congestion, inflammation, calcification, and seromucous gland density between the study and control groups (P > .05). In light microscopic evaluation, moderate density of lymphocytic cells beneath the surface epithelium and, further down, seromucous gland structures, dense seromucous glands, and occasional ductal structures were observed in the study group. Congested vascular structures beneath the respiratory epithelium and adjacent to a thick-walled vascular structure, coarse calcification is observed in the control group. Conclusion: It has been demonstrated that the Allicin-soaked Merocel pack does not have adverse effects on rabbit nasal mucosa, and it does not lead to mucosal bleeding, congestion, inflammation, and calcification, and changes in the seromucous gland density. Considering the antibacterial and antiviral effects of allicin, it is appropriate to plan research in humans to evaluate its use in nasal packs applied during epistaxis, septoplasty, rhinoplasty, and endoscopic sinus surgery.
dc.identifier.doi10.1177/01455613241257354
dc.identifier.endpage68S
dc.identifier.issn0145-5613
dc.identifier.issn1942-7522
dc.identifier.issue3_SUPPL
dc.identifier.pmid38783614
dc.identifier.scopus2-s2.0-85206923936
dc.identifier.scopusqualityQ2
dc.identifier.startpage63S
dc.identifier.urihttps://doi.org/10.1177/01455613241257354
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25007
dc.identifier.volume103
dc.identifier.wosWOS:001230616400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofEnt-Ear Nose & Throat Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectallicin; nasal mucosa; rabbit; bleeding; congestion; inflammation
dc.titleInvestigation of the Effects of Allicin on the Nasal Mucosa
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu