Investigation of GSTM1 and GSTT1 polymorphisms in obesity patients under bariatric surgery

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dc.contributor.authorÜnsal, Abdulkadir
dc.contributor.authorBuluş, Hakan
dc.contributor.authorDirican, Onur
dc.contributor.authorOğuztüzün, Serpil
dc.contributor.authorÖztürk, Doğan
dc.contributor.authorCihan, Mehmethan
dc.contributor.authorAda, Ahmet Oğuz
dc.date.accessioned2025-01-21T16:27:50Z
dc.date.available2025-01-21T16:27:50Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObesity is a chronic disorder with increasing prevalence worldwide and occurs when energy intake is more than energy expenditure. Obesity is one of the factors that cause oxidative stress and arises from an imbalance between the reactive oxygen species ROS and the cell’s antioxidant defense system. Increasing ROS in obesity, influencing the hypothalamic neurons, affect hunger and satiety control, so correspondingly on body weight control. When ROS amount increases, through DNA, protein, and lipid oxidation, cell damage, necrosis, and apoptosis take place. Oxidative stress increment in adipose tissue causes the development of metabolic syndrome in obese people. Also, weight loss due to calorie restriction or exercise reduces oxidative stress. Mitochondria is the essential source for ROS formation. In the electron transfer system, reactive oxygen species forming due to oxidative phosphorylation reactions are involved in various physiological processes such as cell proliferation and differentiation. Glutathione S-transferase M1 and T1 genes encode enzymes that have oxidant-scavenging activities. Deletion polymorphisms in these genes cause the absence of their corresponding enzymes. In this study, we investigated the parameters associated with obesity such as body mass index (BMI), TSH, glucose, satiety blood glucose, triglyceride, and cholesterol levels, and deletion polymorphisms of GSTM1 and GSTT1 genes in 152 patients diagnosed with obesity in a Turkish population. No statistically significant relationship was found between the parameters studied in obese patients and GSTM1 and GSTT1 polymorphisms. More studies are needed to elucidate the relationship of GSTM1 and GSTT1 polymorphisms with obesity. © 2021 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.
dc.identifier.endpage146
dc.identifier.issn1300-4182
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85110064300
dc.identifier.scopusqualityQ4
dc.identifier.startpage139
dc.identifier.trdizinid510997
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/510997
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23429
dc.identifier.volume46
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherSociety of Pharmaceutical Sciences of Ankara (FABAD)
dc.relation.ispartofFabad Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectGSTM1; GSTT1; Multiplex PCR; Obesity; Oxidative stress; Polymorphism
dc.titleInvestigation of GSTM1 and GSTT1 polymorphisms in obesity patients under bariatric surgery
dc.title.alternativeBariatrik cerrahi olmuş obezite hastalarında gstm1 ve gstt1polimorfizmlerininaraştırılması
dc.typeArticle

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