The role of event related potentials in evaluation of subclinical cognitive dysfunction in epileptic patients

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dc.contributor.authorOzmenek, Ozlem Aksoy
dc.contributor.authorNazliel, B.
dc.contributor.authorLeventoglu, A.
dc.contributor.authorBilir, E.
dc.date.accessioned2020-06-25T17:44:32Z
dc.date.available2020-06-25T17:44:32Z
dc.date.issued2008
dc.departmentKırıkkale Üniversitesi
dc.descriptionNazliel, Bijen/0000-0002-6148-3814
dc.description.abstractBackground/Aim : Cognitive dysfunction ill epileptic patients may develop due to the neurophysiological changes related to seizures or antiepileptic drugs. The aim of this study was to evaluate the cognitive dysfunction ill epileptic patients under antiepileptic drug therapy by the aid of event related potentials. Method: P300 latencies were obtained from F-z, C-z and P-z electrod positions from both epileptic patients (n = 40) and age and sex matched control group (n = 40). Epileptic patients were, classified either idiopathic primary generalized (IPGE) (n = 9) or secondary generalized epilepsy (SGE) (n = 31) based oil the ILAE classification The effect of epilepsy hype, treatment types (monotherapy/polytherapy), daily dosages and serum levels of antiepileptic drugs, age at onset and EEG abnormalities oil P300 latencies were studied. Results : P300 latencies were longer ill the epileptics when compared to controls (P < 0.05). Besides, our results pointed out that P300 latencies were longer ill IPGE when compared to SGE (P < 0.05). No statistically significant difference was determined between ERP parameters neither ill monotherapy nor ill polytherapy groups (p > 0.05). Antiepileptic drug subgroups revealed variable effects on ERP latencies. Conclusion : We believe P300 latencies may have all important role in the evaluation of subclinical cognitive dysfunction in epileptic patients treated with antiepileptic drags.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage63en_US
dc.identifier.issn0300-9009
dc.identifier.issn2240-2993
dc.identifier.issue2en_US
dc.identifier.pmid18795598
dc.identifier.scopus2-s2.0-52149116741
dc.identifier.scopusqualityQ2
dc.identifier.startpage58en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4136
dc.identifier.volume108en_US
dc.identifier.wosWOS:000259225000005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofActa Neurologica Belgica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThe role of event related potentials in evaluation of subclinical cognitive dysfunction in epileptic patientsen_US
dc.typeArticle

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