Postoperative 5-fluorouracil versus intraoperative mitomycin C in high-risk glaucoma filtering surgery: extended follow up

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dc.contributor.authorAkarsu, C.
dc.contributor.authorOnol, M.
dc.contributor.authorHasanreisoglu, B.
dc.date.accessioned2020-06-25T17:35:28Z
dc.date.available2020-06-25T17:35:28Z
dc.date.issued2003
dc.departmentKırıkkale Üniversitesi
dc.description.abstractPurpose: To compare the long-term efficacy and safety of postoperative subconjunctival 5-fluorouracil (5-FU) injections with that of intraoperative mitomycin C (MMC) in eyes at high risk for failure of trabeculectomy. Methods: In a retrospective, non-randomized comparative trial, 36 eyes of 36 consecutive patients at high risk for failure of trabeculectomy underwent glaucoma filtering surgery with either postoperative subconjunctival 5-FU injections (19 eyes) or intraoperative application of MMC (17 eyes). Intraocular pressure, number of postoperative antiglaucoma medications, postoperative visual acuity, interventions, and complications were evaluated. Results: Overall success (intraocular pressure less than or equal to21 mmHg) at 1 year was 73.6% in the 5-FU group and 82.3% in the MMC group. The cumulative 4-year success was 52.6% in the 5-FU group and 60.5% in the MMC group (P = 0.6). At 4-year follow up, mean +/- SD intraocular pressures were 17.58 +/- 4.01 mmHg in the 5-FU group and 13.33 +/- 3.36 mmHg in the MMC group (P = 0.01). There was no significant difference in the number of post-operative medications (P = 0.84), appearance of blebs (P = 0.20), final visual acuity (P = 1.00), and complications (P > 0.05) between the groups. Conclusions: These results suggest that both postoperative 5-FU injections and intraoperative MMC application have long-term success in high-risk patients. However, MMC results in a greater decrease in intraocular pressure than 5-FU.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1046/j.1442-9071.2003.00645.x
dc.identifier.endpage205en_US
dc.identifier.issn1442-6404
dc.identifier.issue3en_US
dc.identifier.pmid12786769
dc.identifier.scopus2-s2.0-0038152984
dc.identifier.scopusqualityQ1
dc.identifier.startpage199en_US
dc.identifier.urihttps://doi.org/10.1046/j.1442-9071.2003.00645.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3127
dc.identifier.volume31en_US
dc.identifier.wosWOS:000183348500006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Publishing Asiaen_US
dc.relation.ispartofClinical And Experimental Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject5-fluorouracilen_US
dc.subjectglaucomaen_US
dc.subjectmitomycin Cen_US
dc.subjecttrabeculectomyen_US
dc.subjecthigh-risk surgeryen_US
dc.titlePostoperative 5-fluorouracil versus intraoperative mitomycin C in high-risk glaucoma filtering surgery: extended follow upen_US
dc.typeArticle

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