Targeted delivery of etoposide to osteosarcoma cells using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles

Yükleniyor...
Küçük Resim

Tarih

2017

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Tubitak Scientific & Technical Research Council Turkey

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Folic acid (FA)-functionalized poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles were prepared to enhance the delivery efficiency of the anticancer drug etoposide for the clinical treatment of osteosarcoma. PHBV nanoparticles were synthesized by emulsification/solvent evaporation technique and obtained in the size range of 200-250 nm and zeta potential range of -21 and -27 mV. Encapsulation efficiency and in vitro drug release were studied. The cytotoxic, apoptotic, and necrotic effects of PHBV nanoparticles were also investigated using Saos-2 osteosarcoma cells. The results obtained in this study demonstrate that etoposide-loaded and FA-functionalized PHBV nanoparticles can be successfully used for targeted treatment of osteosarcoma.

Açıklama

CIRAK, Tamer/0000-0003-0431-9919; Alp, Esma/0000-0002-6650-0759; GUVEN, EYLEM/0000-0001-9039-1698

Anahtar Kelimeler

PHBV nanoparticle, folate targeting, etoposide, targeted drug delivery, osteosarcoma

Kaynak

Turkish Journal Of Biology

WoS Q Değeri

Q4

Scopus Q Değeri

Q1

Cilt

41

Sayı

5

Künye

Alp E., Çırak T., Demirbilek M., Türk M., Güven E. (2017). Targeted delivery of etoposide to osteosarcoma cells using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles. Turkish Journal of Biology, 41(5), 719 - 733.