Evaluation of Serum Lipid Parameters in Acromegaly Patients

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dc.contributor.authorKeskin, Havva
dc.contributor.authorCadirci, Kenan
dc.contributor.authorKaya, Yasemin
dc.contributor.authorDurmaz, Senay
dc.contributor.authorArslan, Abdulmuttalip
dc.contributor.authorYildiz, Faruk
dc.contributor.authorCarlioglu, Ayse
dc.date.accessioned2020-06-25T18:34:02Z
dc.date.available2020-06-25T18:34:02Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionKeskin, Havva/0000-0003-1794-4473
dc.description.abstractObjective: In acromegaly, the incidence of cardiovascular disease is higher compared to healthy population because of the association of secondary cardiovascular disease risk factors such as hypertension, glucose intolerance, dyslipidemia, and insulin resistance. This study aimed to evaluate the relationship between Growth Hormone (GH), Insulin-like Growth Factor-1 (IGF-1), and lipid profiles in patients with newly diagnosed acromegaly. Methods: This study included 57 newly diagnosed acromegaly patients and 31 healthy control cases. Blood samples were taken after a 12-hour night fasting to analyze the levels of the hormones, the lipid profiles, and the fasting blood glucose. Results: The mean of LDL-C level in the acromegaly group and control group were respectively 140.2 +/- 61.3 mg/dL and 115.6 +/- 30.4 mg/dL, (p=0.029), triglyceride level 137.6 +/- 84.0 mg/dL and 102.9 +/- 43.0 mg/dL, (p=0.027) and HDL-C level 41.5 +/- 10.5 mg/dL and 50.5 +/- 10.6 mg/dL, (p=0.001). There was a significant positive correlation between GH levels of LDL (r=0.375, p=0.002), TG (r=0.302, p=0.01), IGF-1 (r=0.634, p=0.0001) and HOMA-IR (r=0.699, p=0.0001), IGF-1 and LDL levels (r=0.295, p=0.01) and TG (r=0.476, p=0.0001). There was a negative correlation between HDL and GH (r=-0.399, p=0.001) and HDL with IGF-1 (r=-0.310, p=0.01). Conclusions: Acromegaly is a disorder characterized by an excess of GH and GH appears to adversely affect the lipid profile. It can be considered that this risk factor may be eliminated by the control of the levels of GH and IGF-1 in acromegaly patients. Further studies seem necessary for more clarifica-tion.en_US
dc.identifier.citationKeskin, H., Cadirci, K., Kaya, Y., Durmaz, S., Arslan, A., Yildiz, F., ... Gozcu, H.(2019). Evaluation of Serum Lipid Parameters in Acromegaly Patients. MEDICAL JOURNAL OF BAKIRKOY , vol.15, no.2, 150-154.en_US
dc.identifier.doi10.4274/BTDMJB.galenos2018.20180324112843
dc.identifier.endpage154en_US
dc.identifier.issn1305-9319
dc.identifier.issn1305-9327
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85068142380
dc.identifier.scopusqualityQ4
dc.identifier.startpage150en_US
dc.identifier.urihttps://doi.org/10.4274/BTDMJB.galenos2018.20180324112843
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7761
dc.identifier.volume15en_US
dc.identifier.wosWOS:000475503600005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isotr
dc.publisherYerkure Tanitim & Yayincilik Hizmetleri A Sen_US
dc.relation.ispartofMedical Journal Of Bakirkoy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcromegalyen_US
dc.subjectdyslipidemiasen_US
dc.subjectatherosclerosisen_US
dc.titleEvaluation of Serum Lipid Parameters in Acromegaly Patientsen_US
dc.typeArticle

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