Role of Treg in immune regulation of allergic diseases

Basit Öğe Kaydı
dc.contributor.authorPalomares, Oscar
dc.contributor.authorYaman, Görkem
dc.contributor.authorAzkur, Ahmet Kürşat
dc.contributor.authorAkkoç, Tunç
dc.contributor.authorAkdis, Mübeccel
dc.contributor.authorAkdis, Cezmi A.
dc.date.accessioned2020-06-25T17:51:14Z
dc.date.available2020-06-25T17:51:14Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.descriptionPalomares, Oscar/0000-0003-4516-0369
dc.description.abstractAllergy is a Th2-mediated disease that involves the formation of specific IgE antibodies against innocuous environmental substances. The prevalence of allergic diseases has dramatically increased over the past decades, affecting up to 30% of the population in industrialized countries. The understanding of mechanisms underlying allergic diseases as well as those operating in non-allergic healthy responses and allergen-specific immunotherapy has experienced exciting advances over the past 15 years. Studies in healthy non-atopic individuals and several clinical trials of allergen-specific immunotherapy have demonstrated that the induction of a tolerant state in peripheral T cells represent a key step in healthy immune responses to allergens. Both naturally occurring thymus-derived CD4(+)CD25(+)FOXP3(+) Treg and inducible type 1 Treg inhibit the development of allergy via several mechanisms, including suppression of other effector Th1, Th2, Th17 cells; suppression of eosinophils, mast cells and basophils; Ab isotype change from IgE to IgG4; suppression of inflammatory DC; and suppression of inflammatory cell migration to tissues. The identification of the molecules involved in these processes will contribute to the development of more efficient and safer treatment modalities.en_US
dc.description.sponsorshipSwiss National FoundationSwiss National Science Foundation (SNSF) [32-125249, 32-118226]; Global Allergy and Asthma European Network; Christine Kuhne-Center for Allergy Research and Education (CK-CARE); Ministerio de Educacion y CienciaSpanish Government; FECYT (Spain)en_US
dc.description.sponsorshipThe M. Akdis and C.A. Akdis laboratories' are supported by the Swiss National Foundation grants 32-125249 and 32-118226, Global Allergy and Asthma European Network (GA2LEN), and Christine Kuhne-Center for Allergy Research and Education (CK-CARE). We thank Ministerio de Educacion y Ciencia and FECYT (Spain) for a postdoctoral fellowship to O. Palomares.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/eji.200940045
dc.identifier.endpage1240en_US
dc.identifier.issn0014-2980
dc.identifier.issn1521-4141
dc.identifier.issue5en_US
dc.identifier.pmid20148422
dc.identifier.scopus2-s2.0-77951717543
dc.identifier.scopusqualityQ2
dc.identifier.startpage1232en_US
dc.identifier.urihttps://doi.org/10.1002/eji.200940045
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4750
dc.identifier.volume40en_US
dc.identifier.wosWOS:000278343500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofEuropean Journal Of Immunology
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllergyen_US
dc.subjectAllergen-specific immunotherapyen_US
dc.subjectToleranceen_US
dc.subjectTregen_US
dc.titleRole of Treg in immune regulation of allergic diseasesen_US
dc.typeReview Article

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