Ultrastructural damage in vascular endothelium in rats treated with paclitaxel and doxorubicin

Basit Öğe Kaydı
dc.contributor.authorYamaç, Deniz
dc.contributor.authorElmas, Çiğdem
dc.contributor.authorÖzoğul, Candan
dc.contributor.authorKeskil, Zuhal
dc.contributor.authorDursun, Ayşe
dc.date.accessioned2020-06-25T17:41:17Z
dc.date.available2020-06-25T17:41:17Z
dc.date.issued2006
dc.departmentKırıkkale Üniversitesi
dc.descriptionMeeting of the Society-for-Ultrastructural-Pathology/Annual Session of the United-States-and-Canadian-Academy-of-Pathology -- FEB, 2005 -- San Antonio, TX
dc.description.abstractEndothelium is the first physiological barrier between blood and tissues and can be injured by physical or chemical stress, particularly by the drugs used in the cancer therapy. Paclitaxel and doxorubicin are frequently used anticancer drugs and their cardiac side effects are well observed in clinical setting. Their side effects on the endothelium are still not clear enough. There are few investigations assessing the damages elicited by the combination use of chemotherapy agents in animal experimental models. The purpose of this study was to examine and compare the side effects of doxorubicin and paclitaxel on endothelium in vivo. The drugs were administered weekly to rats via intraperitoneal injections singly or in combinations. Lastly, aorta endothelium was examined. The most familiar parts of the aorta endothelium are the nucleus, free ribosomes, Weibel-Palada granules, plasmalemmal vesicles, and clear basement membrane. Examination of the endothelium and the related structures revealed some clear degenerative findings. Notably, administration of a paclitaxel and doxorubicin combinations caused the most dramatic change in ultrastructure, which may disrupt many functions of the endothelium.en_US
dc.description.sponsorshipSoc Ultrastructural Pathol, US Canadian Acad Patholen_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/01913120500406335
dc.identifier.endpage110en_US
dc.identifier.issn0191-3123
dc.identifier.issue1-2en_US
dc.identifier.pmid16517476
dc.identifier.scopus2-s2.0-33646008619
dc.identifier.scopusqualityQ3
dc.identifier.startpage103en_US
dc.identifier.urihttps://doi.org/10.1080/01913120500406335
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3675
dc.identifier.volume30en_US
dc.identifier.wosWOS:000238155000012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofUltrastructural Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdoxorubicinen_US
dc.subjectendothelium damageen_US
dc.subjectpaclitaxelen_US
dc.subjectultrastructureen_US
dc.titleUltrastructural damage in vascular endothelium in rats treated with paclitaxel and doxorubicinen_US
dc.typeArticle

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