Role of silymarin (Silybum marianum) in the prevention of colistin-induced acute nephrotoxicity in rats

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dc.contributor.authorDumludag, Burak
dc.contributor.authorDerici, Mehmet Kursat
dc.contributor.authorSutcuoglu, Osman
dc.contributor.authorOgut, Betul
dc.contributor.authorPasaoglu, Ozge Tugce
dc.contributor.authorGonul, Ipek Isik
dc.contributor.authorDerici, Ulver
dc.date.accessioned2021-01-14T18:10:48Z
dc.date.available2021-01-14T18:10:48Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionOgut, Betul/0000-0002-1385-7324; Pasaoglu, Ozge Tugce/0000-0002-5221-9034; DERICI, ULVER/0000-0002-9741-6779; sutcuoglu, osman/0000-0003-3835-2741
dc.description.abstractSilymarin (Silybum marianum) has some protective effects against drug toxicity (cisplatin, acetaminophen, adriamycin, gentamicin etc.). Colistin is a strong antimicrobial, which is frequently used in the treatment of resistant gram-negative bacterial infections in recent years although it has nephrotoxic potential. This study was aimed to determine the role of silymarin against colistin-induced acute nephrotoxicity (CIN). Rats were randomly divided into four groups. The control group was treated with tap water whereas groups 2 and 3 received silymarin (orally, 100 mg/kg/day) and colistin (intraperitoneally, 750.000 IU/kg/day) for seven days, respectively. Group 4 received both 750,000 IU/kg/day colistin and 100 mg/kg/day silymarin for seven days. After euthanasia, histopathological and biochemical examinations were completed for the kidney tissue specimens and blood samples. All parameters of the control and silymarin groups were similar. Severe weight loss was seen in the groups receiving colistin (groups 3 and 4). Silymarin significantly increased glutathione peroxidase and superoxide dismutase levels when administered with colistin in group 4 only. Acute tubular injury, tubular necrosis, meduller congestion, interstitial inflammation and apoptotic indices of colistin group were significantly higher than the control group. The administration of colistin with silymarin (group 4) was able to make some improvements in tubular necrosis and significant increase in antioxidant capacity. Silymarin increased antioxidant enzyme activity only when used in combination with colistin. The effects of silymarin may become more pronounced when used at higher doses or with a longer duration of treatment and may prevent nephrotoxicity.en_US
dc.description.sponsorshipTurkish Society of Hypertension and Kidney Diseasesen_US
dc.description.sponsorshipThis study was supported by Turkish Society of Hypertension and Kidney Diseases.en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1080/01480545.2020.1733003
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.pmid32174194
dc.identifier.scopus2-s2.0-85081715437
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1080/01480545.2020.1733003
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12776
dc.identifier.wosWOS:000520339700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofDRUG AND CHEMICAL TOXICOLOGY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSilymarinen_US
dc.subjectcolistinen_US
dc.subjectnephrotoxicityen_US
dc.subjectapoptosisen_US
dc.subjectantioxidanten_US
dc.titleRole of silymarin (Silybum marianum) in the prevention of colistin-induced acute nephrotoxicity in ratsen_US
dc.typeArticle

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