The Efficacy of Gabapentin plus Dexamethasone for Postoperative Analgesia Following Septoplasty: A Prospective Randomized Placebo-Controlled Trial

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dc.authoridPamuk, Erim/0000-0002-8813-0357
dc.authoridKANDEMIR, SUHEYLA/0000-0003-3354-2212
dc.contributor.authorKandemir, Suheyla
dc.contributor.authorPamuk, A. Erim
dc.contributor.authorOzel, Gokce
dc.contributor.authorGencay, Isin
dc.contributor.authorKilic, Rahmi
dc.date.accessioned2025-01-21T16:45:28Z
dc.date.available2025-01-21T16:45:28Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAims: This study aimed to compare the efficacy of gabapentin, dexamethasone, and gabapentin + dexamethasone for pain control after septoplasty. Materials and Methods: This prospective randomized trial included 120 patients that underwent septoplasty and were randomly divided into 4 groups: group G (preoperative gabapentin 600 mg p.o.); group D (intraoperative dexamethasone 8 mg i.v.); group GD (preoperative gabapentin 600 mg p.o. + intraoperative dexamethasone 8 mg i.v.); group C (placebo control). Results: The median VAS score was significantly lower in groups G and GD at 1, 2, 4, 6, 12, and 24 hours postsurgery than in group C (P < .008 for all). The median VAS score was significantly lower in group D than in group C at 1, 2, and 4 hours postsurgery (P < .008 for all). There weren't any significant differences in the VAS score between groups D, G, and GD at any time point. Groups G, D, and GD had a significantly lower frequency of rescue analgesic use than group C; however, there were no differences between groups G, GD, and C (P < .001 and P = .108, respectively). Conclusion: Gabapentin, dexamethasone, and gabapentin + dexamethasone are equally more effective analgesics during the first 4 hours postsurgery than placebo. The addition of dexamethasone to gabapentin does not provide extra analgesia. Both gabapentin and gabapentin + dexamethasone have a more prolonged analgesic effect than dexamethasone alone.
dc.identifier.doi10.1177/00034894221089162
dc.identifier.endpage309
dc.identifier.issn0003-4894
dc.identifier.issn1943-572X
dc.identifier.issue3
dc.identifier.pmid35450447
dc.identifier.startpage304
dc.identifier.urihttps://doi.org/10.1177/00034894221089162
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25654
dc.identifier.volume132
dc.identifier.wosWOS:000786619600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofAnnals of Otology Rhinology and Laryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectgabapentin; dexamethasone; analgesia; postoperative pain; septoplasty
dc.titleThe Efficacy of Gabapentin plus Dexamethasone for Postoperative Analgesia Following Septoplasty: A Prospective Randomized Placebo-Controlled Trial
dc.typeArticle

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