Changes in cardiac cells due to ticagrelor and enoxaparin in a rat ischemia/reperfusion model

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dc.authoridYazir, Yusufhan/0000-0002-8472-0261
dc.authoridfindik, orhan/0000-0001-6959-7069
dc.authoridkavram, kubra/0000-0001-9973-8619
dc.authoridYardimoglu, Melda/0000-0001-5463-2634
dc.authoridBARIS, OZGUR/0000-0002-7231-4709
dc.authoridTekeli Kunt, Atike/0000-0001-9764-7393
dc.authoridFurat Rencber, Selenay/0000-0002-0501-1679
dc.contributor.authorFindik, Orhan
dc.contributor.authorBaris, Ozgur
dc.contributor.authorYazir, Yusufhan
dc.contributor.authorYilmaz, Melda Yardimoglu
dc.contributor.authorRencber, Selenay Furat
dc.contributor.authorSarihan, Kubra Kavram
dc.contributor.authorKunt, Atike Tekeli
dc.date.accessioned2025-01-21T16:36:31Z
dc.date.available2025-01-21T16:36:31Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractOBJECTIVE: Studies on ischemia/reperfusion injury remain the focus of interest. Ticagrelor and enoxaparin, which are antiaggregant and anticoagulant drugs developed for use in many cardiovascular pathologies, are still included in many ischemia/reperfusion studies. Remarkably, their new protective effects, especially with regard to ticagrelor, continue to be reported in the current literature. The aim of this study was to evaluate the beneficial effects of ticagrelor and enoxaparin pretreatments on the rat heart with histological and immunohistochemical markers in an ischemia/reperfusion model. METHODS: Wistar-albino rats (weighing 350-400 g) were divided into four groups as follows: Sham-Control (Group 1), Control-Saline+ischemia/reperfusion (Group 2), Ticagrelor+ischemia/reperfusion (Group 3), and Enoxaparin+ischemia/reperfusion (Group 4). The ischemia/reperfusion injury model was applied to Group 2, Group 3 and Group 4. Heart tissue sections were stained with hematoxylin and eosin for histological examinations. Caspase 3 immunostaining was evaluated to detect apoptosis in the heart tissue sections. RESULTS: Both pretreatments ameliorated the ischemic damage but especially tissue sections belonging to Group 3 were nearly similar to control levels. The results indicated that ischemia/reperfusion-induced myocardial damage was significantly increased in Group 2, whereas ticagrelor and enoxaparin pretreatments in Group 3 and Group 4 significantly decreased apoptotic scores and the histological appearance of the Group 3 close to the normal myocardium (p<0.001). CONCLUSION: As supported by histological findings in our study, ticagrelor and enoxaparin have protective properties for heart tissue in this ischemia/reperfusion injury model.
dc.identifier.doi10.1590/1806-9282.20210477
dc.identifier.endpage1770
dc.identifier.issn1806-9282
dc.identifier.issue12
dc.identifier.pmid34909947
dc.identifier.scopus2-s2.0-85121539058
dc.identifier.scopusqualityQ2
dc.identifier.startpage1764
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20210477
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24320
dc.identifier.volume67
dc.identifier.wosWOS:000756351300007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssoc Medica Brasileira
dc.relation.ispartofRevista Da Associacao Medica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectTicagrelor; Enoxaparin; Ischemia; Rats; Reperfusion injury
dc.titleChanges in cardiac cells due to ticagrelor and enoxaparin in a rat ischemia/reperfusion model
dc.typeArticle

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