Hyperhomocysteinemia Predicts the Severity of Coronary Artery Disease as Determined by the SYNTAX Score in Patients with Acute Coronary Syndrome

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dc.contributor.authorKaradeniz, Muhammed
dc.contributor.authorSarak, Toner
dc.contributor.authorDuran, Mustafa
dc.contributor.authorAlp, Caglar
dc.contributor.authorKandemir, Huseyin
dc.contributor.authorCelik, Ibrahim Etem
dc.contributor.authorkilic, Alparslan
dc.date.accessioned2020-06-25T18:29:21Z
dc.date.available2020-06-25T18:29:21Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: Hyperhomocysteinemia is a known risk factor for acute coronary syndrome (ACS) and is related with the severity of coronary artery disease (CAD). Previous studies have used less quantifiable scoring systems for assessing the severity of CAD. Therefore, we aimed to assess the relationship between homocysteine levels and SYNTAX score (SXscore), which is currently more widely used to grade the severity of CAD. Methods: A total of 503 patients with adiagnosis of ACS were examined angiographically with SXscore. The patients were divided into three groups according to SXscore; Group 1 a low SXscore <= 22), Group 2 a moderate SXscore (23-32), and Group 3 a high SXscore (>= 33). Results: Plasma homocysteine levels were 16.3 +/- 6.2 nmol/mL in Group 1, 18.1 +/- 9.6 nmol/mL in Group 2, and 19.9 +/- 9.5 nmol/mL in Group 3. Homocysteine levels were significantly higher in Group 2, and Group 3 compared to Group 1 (p = 0.023 and 0.007, respectively). In the correlation analysis, homocysteine levels were correlated with SXscore (r: 0.166, p < 0.01). Conclusions: Serum homocysteine levels on admission were associated with an increased severity of CAD in the patients with ACS.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.6515/ACS.201811_34(6).20180528B
dc.identifier.endpage463en_US
dc.identifier.issn1011-6842
dc.identifier.issue6en_US
dc.identifier.pmid30449985
dc.identifier.scopus2-s2.0-85057184703
dc.identifier.scopusqualityQ3
dc.identifier.startpage458en_US
dc.identifier.urihttps://doi.org/10.6515/ACS.201811_34(6).20180528B
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7264
dc.identifier.volume34en_US
dc.identifier.wosWOS:000449890000002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaiwan Soc Cardiologyen_US
dc.relation.ispartofActa Cardiologica Sinica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute coronary syndromeen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectHomocysteineen_US
dc.subjectSYNTAX scoreen_US
dc.titleHyperhomocysteinemia Predicts the Severity of Coronary Artery Disease as Determined by the SYNTAX Score in Patients with Acute Coronary Syndromeen_US
dc.typeArticle

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