Intraocular Pressure Lowering Effect of Orbital Decompression is Related to Increased Venous Outflow in Graves Orbitopathy

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dc.contributor.authorOnaran, Zafer
dc.contributor.authorKonuk, Onur
dc.contributor.authorOktar, Suna Ozhan
dc.contributor.authorYucel, Cem
dc.contributor.authorUnal, Mehmet
dc.date.accessioned2020-06-25T18:12:11Z
dc.date.available2020-06-25T18:12:11Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.description.abstractPurpose: To investigate the effects of combined orbital bone and fat decompression on intraocular pressure (IOP) and superior ophthalmic vein blood flow velocity (SOV-BFV), and their association with the clinical features of Graves orbitopathy (GO). Methods: During the 2002-2008 period, 72 eyes of 36 GO cases demonstrating moderate to severe orbitopathy were evaluated according to their clinical features as: cases with or without dysthyroid optic neuropathy (DON), and underwent orbital decompression. A control group comprised 40 eyes of 20 healthy subjects. In both groups, a full ophthalmic examination including IOP and Hertel measurements was performed, and SOV-BFV was analyzed with color Doppler imaging. Examinations were repeated after orbital decompression in GO patients. Results: All the cases demonstrated clinical features of inactive disease. Among the patients 24 of 72 eyes (33.3%) showed clinical features of DON. After surgery, the mean decrease in Hertel values was 6.2 +/- 1.8mm (p = 0.001). The mean decrease in IOP was 3.0 +/- 1.7mmHg (from 17.3 +/- 2.7 to 14.3 +/- 2.0mmHg) after orbital decompression where the post-operative values were comparable with the control group (12.9 +/- 1.4mmHg, p = 0.36). The mean increase in SOV-BFV achieved with decompression was 1.2 +/- 0.6 cm/s (from 4.8 +/- 1.7 to 6.0 +/- 1.8 cm/s) and post-operative SOV-BFV values were also comparable with the control group (6.6 +/- 1.3 cm/s, p = 0.26). The increase in SOV-BFV in cases with DON did not differ from cases without DON (p = 0.32), however, post-operative SOV-BFV of cases with DON was stil lower than cases without DON (p = 0.035). Conclusions: Combined orbital bone and fat decompression significantly reduced the IOP levels and increased the SOV-BFV in GO. This could be the confirmative finding of prediction that elevated IOP in GO is associated with increased episcleral venous pressure. The post-operative changes in IOP and SOV-BFV show differences regarding the clinical features of disease.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.3109/02713683.2013.867355
dc.identifier.endpage672en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue7en_US
dc.identifier.pmid24502333
dc.identifier.scopus2-s2.0-84901829098
dc.identifier.scopusqualityQ1
dc.identifier.startpage666en_US
dc.identifier.urihttps://doi.org/10.3109/02713683.2013.867355
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5790
dc.identifier.volume39en_US
dc.identifier.wosWOS:000336995500003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInforma Healthcareen_US
dc.relation.ispartofCurrent Eye Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDysthyroid optic neuropathyen_US
dc.subjectGraves orbitopathyen_US
dc.subjectintraocular pressureen_US
dc.subjectorbital decompressionen_US
dc.subjectsuperior ophthalmic veinen_US
dc.titleIntraocular Pressure Lowering Effect of Orbital Decompression is Related to Increased Venous Outflow in Graves Orbitopathyen_US
dc.typeArticle

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