Stereological and biochemical evaluation of diclofenac-induced acute nephrotoxicity in rats

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dc.contributor.authorBolat, D.
dc.contributor.authorSelcuk, M. L.
dc.date.accessioned2020-06-25T18:07:11Z
dc.date.available2020-06-25T18:07:11Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.descriptionSelcuk, Muhammet Lutfi/0000-0002-9915-3829
dc.description.abstractThe aim of this study was to evaluate the effects of diclofenac-induced acute nephrotoxicity using stereological and biochemical parameters in rats. For that, 20 male Wistar rats allotted in 4 equal groups were intraperitoneally injected by 0, 10, 50 and 100 mg/kg diclofenac, respectively and 8 hours after injection, blood serum samples were collected for assessment of urea, creatinine, fibrinogen, antithrombin III, malondialdehyde (MDA), nitric oxide, vitamin C and beta-carotene concentrations and amine deaminase (ADA) and superoxide dismutase (SOD) activities. After slaughtering, left kidneys were stereologically evaluated. Despite slight but more often not significant variations especially observed in rats treated with 50 mg/kg diclofenac, stereological renal parameters, oxidative stress markers and coagulation markers were considered to be within usual values in rats. By contrast, significant and dose related increases in uraemia were evidenced in intoxicated animals. It was concluded that diclofenac-induced kidney damage cannot be evaluated by kidney stereological and serum oxidative stress parameters, however, more severe kidney damage may cause observable alterations in these parameters.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage294en_US
dc.identifier.issn0035-1555
dc.identifier.issn2258-0646
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84878887068
dc.identifier.scopusqualityN/A
dc.identifier.startpage290en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5507
dc.identifier.volume164en_US
dc.identifier.wosWOS:000334093400001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherEcole Nationale Veterinaire Toulouseen_US
dc.relation.ispartofRevue De Medecine Veterinaire
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiclofenacen_US
dc.subjectnephrotoxicityen_US
dc.subjectraten_US
dc.subjectacute toxicityen_US
dc.subjectstereologyen_US
dc.subjectoxidative stressen_US
dc.titleStereological and biochemical evaluation of diclofenac-induced acute nephrotoxicity in ratsen_US
dc.typeArticle

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